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PubMed

Correction: Addressing risk factors for hypertensive disorders in pregnancy: A case study of a quality improvement program in two states in Nigeria.

The Funding statement for this article is incorrect. The correct Funding statement is as follows: This study was financially supported by MSD for Mothers in the form of a grant awarded to and administered to the authors by Jhpiego Corporation. No additional external funding was received for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The Competing Interests statement for this article is incorrect. The...

4 days ago

PubMed

Feasibility and acceptability of a structured counselling approach to address lifestyle-related risk factors during pregnancy and postpartum care: an exploratory longitudinal pilot feasibility study.

Background Lifestyle-related risk factors (LRRFs) are major contributors to adverse maternal and child outcomes. Despite clear international guidelines, counselling on these topics is inconsistently implemented in routine care. Structured tools may support comprehensive, consistent counselling, yet evidence for multi-domain approaches in maternal health is limited. Methods This exploratory longitudinal pilot feasibility study evaluated a structured counselling approach to support structured c...

4 days ago

PubMed

HIF-1α expression is associated to cell proliferation and ECM production in temporomandibular joint osteoarthritis.

Temporomandibular joint osteoarthritis (TMJOA) is a complex joint disorder characterized by progressive degradation of the cartilage matrix and apoptosis of chondrocytes; however, hypoxia-inducible factor 1α (HIF-1α) serves a positive role in maintaining the stability of the articular cartilage matrix. Therefore, the present study aimed to determine the expression levels of HIF-1α in the cartilage tissue of rats with TMJOA, and to explore its association with the proliferation of chondrocytes an...

4 days ago

PubMed

Delayed Inflammatory Reaction to Periorbital Hyaluronic Acid Filler: Relapse After Lisinopril Withdrawal and Response to Retreatment.

Dear Editor, Hyaluronic acid (HA) fillers are widely used for facial and extrafacial rejuvenation and generally well tolerated [1]. Delayed inflammatory reactions (DIRs) may present with edema, erythema, induration, or nodules after an uneventful interval [1]. Their pathogenesis remains uncertain and may involve immune responses, filler degradation, and infectious or biofilm‐related factors; reported triggers include viral infections, sinusitis, dental procedures, different or low‐quality fille...

Nov 5, 2026

PubMed

Chitosan functionalized selenium nanoconjugates of Mucuna pruriens as a nanotherapeutic approach for Parkinson's disease.

Nature’s mother holds many untapped treasures of phytoconstituents that can cure and exhibit unexpected therapeutic activity against several diseases. Seeds of velvet beans, popularly known as Mucuna pruriens (MP), are the richest source of Levodopa (L-DOPA). L-DOPA is the precursor for dopamine, a key neurotransmitter deficient in the brain of patients suffering from Parkinson’s disease (PD). The peripheral degradation of L-DOPA before crossing the blood-brain barrier (BBB) is the greatest chal...

Nov 4, 2026

PubMed

Neoadjuvant Apalutamide With or Without Abiraterone Acetate Plus Prednisone and Gonadotropin-Releasing Hormone Agonist Prior to Nerve-Sparing Radical Prostatectomy in High-Risk Prostate Cancer: Protocol for a Randomized Phase 2 Trial.

Abstract Background Radical prostatectomy (RP) is an accepted, definitive treatment for appropriately selected men with high-risk localized prostate cancer (PCa). However, neoadjuvant androgen receptor inhibition prior to RP is not currently the standard of care. Wide resection of the neurovascular bundles may improve local oncologic control but can adversely affect postoperative erectile function and urinary continence. Apalutamide directly inhibits the androgen receptor, while abiraterone ac...

Nov 3, 2026

PubMed

Laboratory-based assessment of quantitative PCR to describe Arctic fish assemblages in surface water affected by acid rock drainage.

Permafrost thaw has been identified as a cause of metal mobilization from acid rock drainage and transport to Arctic rivers. Elevated metal concentrations and precipitation of Fe(III) minerals (i.e., rusting) in surface waters deteriorates water quality and raises questions about ecosystem effects, especially to the health of fish species. Environmental DNA (eDNA) analyses could be used for assessing impacts of acid rock drainage to fish assemblages but may be prone to biases like polymerase cha...

4 days ago

PLOS

Traditional knowledge of childhood illnesses among the Sidama nation, clinical presentation and hematological findings

Background: Sidama possesses extensive indigenous knowledge regarding infant illnesses described as “feyancho”. Feyancho has a widespread recognition among Sidama people, though poorly documented in scientific literature. This study aimed to document the indigenous understanding of this infantile disease and examine associated clinical and biochemical profiles in the Sidama National Regional State, Ethiopia. Methods: A household-based cross-sectional study was conducted in nine districts selecte...

4 days ago

PLOS

Associations of palmar surface lactic acid with hand scaling and in vitro pathogen inactivation: A cross-sectional study

The relationship between palmar surface lactic acid and hand scaling is not well understood. This cross-sectional study examined associations between palmar surface lactic acid, hand scaling, and in vitro anti-pathogenic activity, to generate hypotheses relevant to hand skin condition and pathogen inactivation. In 49 healthy adults, after standardized hand washing and acclimation (20°C, 40% RH), we assessed scaling (visual score), surface lactic acid and stratum corneum ceramides (LC–MS), stratu...

4 days ago

PubMed

Mathematical modeling and optimal control of immune responses in multiple sclerosis.

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated destruction of the myelin sheath in the central nervous system. In this work, we develop and analyze a mathematical model describing the interactions among myelin, autoreactive immune cells, regulatory immune cells, and treatment. A fast-time reduction of the slow–fast model yields an analytically tractable immune subsystem that captures the principal immune interactions. We establish the existence and stabi...

4 days ago

PubMed

Retraction: Fasciola hepatica excretory-secretory products attenuate demyelination and reduce neuroinflammation in the Cuprizone –induced multiple sclerosis model.

Following the publication of this article [1], the corresponding author requested a correction to Fig 6C and 6D, after concerns were raised about unusually repetitive features appearing in these panels. The corresponding author stated that internal microscope-generated labels were removed from the Fig 6C and 6D image by covering the labelled areas with a portion of the adjacent image. They provided what they described as an original unedited image underlying Fig 6D, and a re-stained and reimaged...

4 days ago

PubMed

Clonal hematopoiesis in autoimmune hemolytic anemia.

Visual Abstract

4 days ago

PubMed

Illness perceptions among adults aged 18–44 years with ankylosing spondylitis: A qualitative study informed by the common-sense model of self-regulation.

Background Ankylosing spondylitis mainly affects people in early and middle adulthood. This period involves important transitions in education, career, relationships, and family. Illness perceptions play an important role in treatment adherence and disease management. Few qualitative studies have examined how Chinese adults perceive and cope with the disease using a clear theoretical framework. Objective This study aimed to explore illness perceptions among adults aged 18–44 years with ankylo...

4 days ago

PubMed

Effectiveness of LGBTQ targeted cognitive behavioral therapy on mental health outcomes: A systematic review and meta-analysis protocol.

Introduction Sexual and gender minority populations experience disproportionately high rates of mental disorders due, in large part, to their chronic exposure to stigma, discrimination, and minority stress. Cognitive behavioral therapy (CBT) is an established evidence-based psychotherapy; however, conventional CBT was primarily developed among predominantly cisgender, heterosexual individuals and not often addresses identity-specific stressors relevant to LGBTQ individuals. Emerging adaptations...

4 days ago

PubMed

Decolonizing mental health: the Nova Scotia transcultural mental health program as a model of care.

Background African Nova Scotians, Indigenous peoples, and refugees experience significant disparities in access to culturally appropriate mental health care due to systemic inequities, intergenerational trauma, stigma, and limited availability of culturally competent services. The Nova Scotia Transcultural Mental Health Program (NSTMHP) was established to close gaps in serving these equity-denied groups using a culturally responsive and collaborative model of care in primary healthcare settings...

4 days ago

Featured Drugs

Recent additions & updates.

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Monjuvi (tafasitamab-cxix)

ONCOLOGY·DLBCL·+2

2 indications · 2 resource groups · Highlights pattern.

Incyte CorporationSponsored

Adalimumab

RHEUMATOLOGY·TNF INHIBITOR

2 indications · 2 resource groups · Highlights pattern.

Libtayo (cemiplimab-rwlc)

ONCOLOGY·NSCLC·+2

3 indications · 4 resource groups · long-form ISI.

RegeneronSponsored

Fotivda (tivozanib HCl)

ONCOLOGY·RCC

2 indications · 2 resource groups · Highlights pattern.

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DCA Vantage Analyzer

HbA1c · Microalbumin/Creatinine

Siemens HealthineersSponsored

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Metrix COVID-Flu Test

SARS-CoV-2 · Influenza A/B

Sekisui DiagnosticsSponsored

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LeadCare II Analyzer

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Magellan DiagnosticsSponsored

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Cardio-Test Stat Panel

Troponin I · CK-MB · BNP

AbbottSponsored

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Afinion 2 Analyzer

HbA1c · Lipid panel · ACR

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ID NOW System

Influenza A/B · Strep A · RSV

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Clinitek Status+

Urinalysis · hCG

Siemens HealthineersSponsored

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CoaguChek Pro II

PT/INR · aPTT

RocheSponsored

From our experts

Editorial & clinical reviews and more…

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Clinical review

2026 Biosimilar Landscape: What Physicians Need to Know

Biosimilars are reshaping prescribing economics across immunology and oncology. This review maps the 2026 approvals, interchangeability designations, and the substitution rules physicians navigate at the point of care — from adalimumab’s crowded field to the newest oncology entrants — with practical guidance on switching, patient communication, and payer coverage that determines what actually reaches the pharmacy counter.

March 21, 2026•8 min read

Treatment guide

Managing RA in the Era of Biosimilars

A practical framework for sequencing conventional DMARDs, biologics, and biosimilars in rheumatoid arthritis. We cover when to switch, how to taper safely, and what to monitor — plus the shared-decision conversations that keep patients on therapy when a formulary change forces a substitution mid-treatment.

March 18, 2026•6 min read

Oncology

CD19-Directed Therapy: A Practitioner’s Guide

CD19-directed agents have moved from trials into everyday oncology practice. This practitioner’s guide covers mechanism of action, patient eligibility, dosing logistics, and the prolonged cytopenias to watch for during combination therapy in relapsed or refractory DLBCL — with a checklist for coordinating care across the treatment team.

March 12, 2026•10 min read

Current issue

Physicians Office Resource Magazine · May 2026

Cover story: AI in public health March 21, 2026

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