Constulose (lactulose)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Lactulose, a synthetic derivative of lactose, is an ammonia detoxicant.

USES: This medication is a laxative used to treat constipation. It may help to increase the number of bowel movements per day and the number of days you have a bowel movement. Lactulose is a colonic acidifier that works by increasing stool water content and softening the stool.

It is a man-made sugar solution.

Generic name: lactulose
Pronunciation: (LACK-tew-lohss)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Constulose:

  • Constipation
  • Hepatic Encephalopathy
  • Hyperammonemia

Also known as: Abnormally Elevated Blood Ammonia, Ammonemia, Portal Systemic Encephalopathy.

Dosing

Each 15 mL of commercially available lactulose solution provides approximately 10 g of the drug; corresponding doses provided by 2.5, 5, 7.5, 10, 30, 40, 45, 90, 150, and 300 mL of the commercial solution are approximately 1.67, 3.3, 5, 6.67, 20, 27, 30, 60, 100, and 200 g, respectively. Following reconstitution of the oral powder as directed, a 10 or 20 g dose is provided by the total volume.

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

There is no enhanced messaging for this drug.

Adverse reactions

There is no enhanced messaging for this drug.

Precautions

No enhanced messaging available.

ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data