Cervidil (dinoprostone)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Dinoprostone, the naturally occurring prostaglandin E2, stimulates uterine smooth muscle and also produces cervical dilation and softening.
Dinoprostone suppositories are used intravaginally to induce abortion during the second trimester of pregnancy (beyond the 12th week of gestation). Continuous IV infusion of a dilute solution of oxytocin usually is used in conjunction with dinoprostone administration to shorten the induction-to-abortion time and reduce the number of dinoprostone doses required and the number of adverse effects. The mean induction-to-abortion time following intravaginal administration of dinoprostone with IV infusion of oxytocin in second trimester pregnancies is 12-14 hours; abortion occurs in about 90% of patients within 30 hours after the initial dose of dinoprostone.
Generic name: dinoprostone
Pronunciation: (dye-no-PROST-own)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
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Indications
The following indications are listed for Cervidil:
- Cervical Ripening Procedure
- Induction Of Labor
Dosing
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Drug interactions
IV infusion of 500 mL of 10% alcohol injection over a period of 1 hour has been reported to inhibit uterine activity that had been initiated and maintained by IV dinoprostone.
Since dinoprostone may increase activity of oxytocic agents, concomitant use of dinoprostone and oxytocics is not recommended. At least 30 minutes should elapse between removal of dinoprostone vaginal insert and initiation of oxytocin therapy, while an interval of 6-12 hours is recommended for the sequential administration of oxytocin after the use of dinoprostone cervical gel.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
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There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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