Dantrolene Sodium (dantrolene sodium)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Dantrolene sodium is a direct-acting skeletal muscle relaxant.
USES: This medication is used to treat muscle tightness and cramping (spasms) caused by certain nerve disorders such as spinal cord injury, stroke, cerebral palsy, and multiple sclerosis. It works by relaxing the muscles. Dantrolene helps reduce muscle pain and stiffness, improves your ability to move around, and lets you do more of your daily activities.
Dantrolene is also used with other treatments to prevent or treat special cases of high fever (malignant hyperthermia) related to anesthesia and surgery.
Generic name: dantrolene sodium
Pronunciation: (DAN-trow-leen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Dantrolene Sodium
Indications
The following indications are listed for Dantrolene Sodium:
- Malignant Hyperthermia
- Malignant Hyperthermia Prevention
- Muscle Spasm
- Muscle Spasticity Of Cerebral Origin
- Muscle Spasticity Of Spinal Origin
Also known as: Involuntary Muscle Contraction, Malignant Hyperthermia Prophylaxis, Muscle Spasticity, Skeletal Muscle Spasm, Spasticity.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
There are no adequate and well-controlled studies of dantrolene in pregnant women. The drug has been shown to be embryocidal in rabbits and to decrease pup survival in rats when given at doses 7 times the human oral dose. Dantrolene sodium readily crosses the placenta but, when given to pregnant women at term in a dosage of 100 mg daily, no adverse respiratory or neuromuscular effects were detected at low dose in neonates born to these women. Further studies are needed, particularly with higher dosages. Dantrolene should not be used in women who are or may become pregnant unless the possible benefits outweigh the potential risks to the fetus.
Dantrolene is distributed into human milk. Because of the potential for serious adverse effects in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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