Isopto Atropine (atropine sulfate)

To produce mydriasis and cycloplegia for refraction in adults, 1 drop of a 1% solution may be instilled onto the eye(s) 1 hour before the procedure. In children, the usual dosage for cycloplegic refraction is 1-2 drops of a 0.5% solution instilled onto the eye(s) twice daily for 1-3 days before the procedure (the 0.5% solution is no longer commercially available in the US). Alternatively, to produce mydriasis and cycloplegia for refraction in adults, 0.3-0.5 cm of a 1% ointment may be placed into the conjunctival sac 1-3 times daily. In children, the usual dosage for cycloplegic refraction is 0.3 cm of a 1% ointment placed into the conjunctival sac 3 times daily for 1-3 days before the procedure. If the ointment is used for refraction, the drug should be applied several hours before the procedure, since it may impair corneal transparency and prevent accurate measurement of refractive errors.

For pupillary dilation in the treatment of acute inflammatory conditions of the iris and uveal tract in adults (i.e., iridocyclitis, uveitis), 1 or 2 drops of a 0.5 or 1% solution may be instilled onto the eye(s) up to 4 times daily. In children, the usual dosage for the treatment of uveitis is 1 or 2 drops of a 0.5% solution up to 3 times daily. Alternatively, for pupillary dilation in the treatment of acute inflammatory conditions of the iris and uveal tract in adults and children, 0.3-0.5 cm of a 1% ointment may be placed into the conjunctival sac up to 3 times daily.

Atropine sulfate is applied topically to the eye in the form of an ophthalmic ointment or solution. To avoid excessive systemic absorption, finger pressure should be applied on the lacrimal sac during and for 1-2 minutes following topical administration of the solution or ointment. Care should be taken to avoid contamination of the ointment tube and solution container.

No dosing information is available for this tab.

No dosing information is available for this tab.

There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

There are no contraindication contraindications for this drug.

There are no severe contraindications for this drug.

• Hypertension

There is no enhanced messaging for this drug.

Rare or Very Rare

• Acute cognitive impairment
• Anticholinergic toxicity
• Ataxia
• Behavioral disorders
• Dizziness
• Drowsy
• Dry skin
• Fatigue
• Fever
• Flushing
• Hallucinations
• Skin rash
• Slurred speech
• Tachycardia
• Unsteady gait
• Xerostomia

Less Frequent

• Blurred vision
• Eyelid edema
• Ocular irritation
• Photophobia

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.