Tryptyr (acoltremon)
Ophthalmic (Eye) Dropperette, Single-Use Drop Dispenser
Last reviewed · Source: First Databank (FDB) drug data
Overview
Acoltremon is a transient receptor potential melastatin 8 (TRPM8) thermoreceptor agonist.
USES: This medication is used to treat dry eye disease. Acoltremon may work by increasing the amount of tears you make.
Generic name: acoltremon
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Tryptyr
Indications
The following indications are listed for Tryptyr:
- Dry Eye
Also known as: Eye Dryness, Xerophthalmia.
Dosing
It isessentialthat the manufacturer's labeling be consulted for more detailed information on dosage and administration of this drug. Dosage summary:
For topical application in the eye.
Instill one drop in each eye twice daily (approximately 12 hours apart).
See Full Prescribing Information for additional instructions on administration.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Tryptyr 0.003% Eye Drop | Maintenance | Instill 1 drop into affected eye(s) by ophthalmic route 2 times per day approximately 12 hours apart. |
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
None.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- No disease contraindications
Adverse reactions
The most common adverse reaction was instillation site pain (50%).
There are no severe adverse reactions for this drug.
More Frequent
- Acute pain at drug application site
Precautions
No enhanced messaging available.
The safety and effectiveness of acoltremon have not been established in pediatric patients.
There are no adequate and well-controlled studies on acoltremon in pregnant women. Systemic exposure to acoltremon from ocular administration is negligible. Intravenous administration of acoltremon to pregnant rats and rabbits during organogenesis did not produce embryofetal toxicity at 806- and 2151-fold the maximum recommended human ocular dose (MRHOD) of acoltremon on a mg/m2 basis.
All pregnancies have a risk of birth defect, loss, or other adverse outcomes. In the US general population, the estimated background risk of major birth defects is 2 to 4%, and of miscarriage is 15 to 20%, of clinically recognized pregnancies.
There are no data on the presence of acoltremon in human milk, the effects on the breastfed infant, or the effects on milk production. However, systemic exposure to acoltremon following topical ocular administration is low. The lack of clinical data during lactation precludes a clear determination of the risk of acoltremon to an infant during lactation; however, the developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for acoltremon.
No clinically relevant differences in safety have been observed between elderly and younger patients.
ICD codes
| Code | Type | Description |
|---|---|---|
| Dry eye | ||
| H04.12 | ICD10CM | Dry eye syndrome |
| H04.121 | ICD10CM | Dry eye syndrome of right lacrimal gland |
| H04.122 | ICD10CM | Dry eye syndrome of left lacrimal gland |
| H04.123 | ICD10CM | Dry eye syndrome of bilateral lacrimal glands |
| H04.129 | ICD10CM | Dry eye syndrome of unspecified lacrimal gland |
| H11.14 | ICD10CM | Conjunctival xerosis, unspecified |
| H11.141 | ICD10CM | Conjunctival xerosis, unspecified, right eye |
| H11.142 | ICD10CM | Conjunctival xerosis, unspecified, left eye |
| H11.143 | ICD10CM | Conjunctival xerosis, unspecified, bilateral |
| H11.149 | ICD10CM | Conjunctival xerosis, unspecified, unspecified eye |
| H16.221 | ICD10CM | Keratoconjunctivitis sicca, not specified as sjogren's, right eye |
| H16.222 | ICD10CM | Keratoconjunctivitis sicca, not specified as sjogren's, left eye |
| H16.223 | ICD10CM | Keratoconjunctivitis sicca, not specified as sjogren's, bilateral |
| H16.229 | ICD10CM | Keratoconjunctivitis sicca, not specified as sjogren's, unspecified eye |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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