Miostat (carbachol)

For the treatment of glaucoma, the concentration and frequency of instillation of carbachol ophthalmic solutions must be adjusted to the requirements and responses of individual patients as determined by tonometric readings before and during therapy. The usual dosage is 1-2 drops of a 0.75-3% ophthalmic solution every 4-8 hours.

The usual intraocular dose of carbachol to produce miosis during surgery is 0.5 mL of a 0.01% injection instilled into the anterior chamber before or after securing sutures.

In the treatment of glaucoma, carbachol is applied topically to the conjunctiva as an ophthalmic solution. Finger pressure should be applied on the lacrimal sac for 1-2 minutes following topical instillation of miotic ophthalmic solutions to minimize drainage into the nose and throat and reduce the risk of absorption and systemic reactions. Excess solution around the eye should be removed with a tissue, and any medication on the hands should be rinsed off immediately.

To produce miosis during surgery, carbachol injection is instilled into the anterior chamber of the eye. For intraocular instillation, the appropriate dose of carbachol injection should be prepared according to the manufacturer's directions. The manufacturer of Miostat(R) states that the appropriate dose of carbachol injection for intraocular use should be withdrawn into a sterile disposable syringe through a 0.45-mcm filter provided by the manufacturer using a 21-gauge needle. Prior to administration, the attached needle and filter should be removed from the syringe and replaced with a suitable atraumatic cannula for intraocular irrigation. Instillation should be gentle and parallel to the iris face and tangential to the pupil border. Unused portions of the injection should be discarded.

No dosing information is available for this tab.

No dosing information is available for this tab.

There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

There are no contraindication contraindications for this drug.

• Abdominal pain with cramps
• Asthma
• Heart failure
• Hyperthyroidism
• Parkinsonism
• Peptic ulcer
• Urinary tract obstructive uropathy

• Bradycardia
• Severe hypotension

There is no enhanced messaging for this drug.

Rare or Very Rare

• Asthma
• Bullous keratopathy
• Cardiac arrhythmia
• Corneal edema
• Hypotension
• Increased urinary frequency
• Iritis
• Ocular hypertension
• Retinal detachment
• Syncope

More Frequent

• Blurred vision
• Ocular pain
• Visual changes

Less Frequent

• Blepharospasm
• Headache disorder
• Ocular irritation

Rare or Very Rare

• Abdominal pain with cramps
• Bladder irritability
• Corneal opacity
• Diarrhea
• Dyspepsia
• Flushing
• Hyperhidrosis
• Nausea
• Ocular inflammation
• Ocular redness
• Vomiting

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.

No enhanced messaging available.