Tobramycin-Loteprednol (tobramycin/loteprednol etabonate)
Ophthalmic Antibacterials Ophthalmic (Eye) Suspension, Drops(Final Dosage Form)(Ml)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Tobramycin is an aminoglycoside antibiotic.
Loteprednol etabonate is a synthetic nonfluorinated corticosteroid.
USES: This medication is used to treat conditions involving swelling (inflammation) of the eyes and to treat or prevent bacterial eye infections. This product contains tobramycin, an antibiotic that works by stopping the growth of bacteria. It also contains loteprednol, an anti-inflammatory corticosteroid that works by reducing swelling, redness, and itching.
This medication treats/prevents only bacterial eye infections. It will not work for other types of eye infections. Using any antibiotic when it is not needed can cause it to not work for future infections.
Generic name: tobramycin/loteprednol etabonate
Pronunciation: (TOE-bra-MYE-sin/LOE-te-PRED-nol)
Drug class: Ophthalmic Antibacterials
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Tobramycin-Loteprednol
Indications
The following indications are listed for Tobramycin-Loteprednol:
- Ocular Inflammation
- Superficial Ocular Infection
Also known as: Ophthalmic Inflammation, Superficial Ophthalmic Infection.
Dosing
Safety and efficacy of ophthalmic suspensions containing loteprednol etabonate alone or in fixed combination with tobramycin have not been established in children younger than 18 years of age.
Loteprednol etabonate alone or in fixed combination with tobramycin is applied topically to the eye as an ophthalmic suspension. The suspension should be shaken vigorously prior to use. Care should be taken to avoid contamination of the container.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
- Fungal infection of eye
- Herpes simplex dendritic keratitis
- Tuberculosis of the eye
- Vaccinia virus keratitis
- Glaucoma
- Ocular hypertension
- No disease contraindications
Adverse reactions
There is no enhanced messaging for this drug.
More Frequent
- Chemosis
Less Frequent
- Keratoconjunctivitis
- Ocular inflammation
- Ocular itching
- Ocular redness
- Uveitis
Rare or Very Rare
- Anaphylaxis
- Bacterial eye infection
- Cataracts
- Erythema multiforme
- Fungal infection of eye
- Glaucoma
- Globe perforation
- Hypersensitivity drug reaction
- Impaired wound healing
- Ocular infection
- Posterior capsule opacification
- Punctate keratitis
- Stevens-johnson syndrome
- Viral ocular infection
More Frequent
- Anterior chamber inflammation
- Blurred vision
- Conjunctival hyperemia
- Corneal edema
- Dry eye
- Eye tearing
- Headache disorder
- Ocular itching
- Ocular pain
- Ocular redness
- Pharyngitis
- Photophobia
- Rhinitis
- Visual changes
Less Frequent
- Blurred vision
- Conjunctival hyperemia
- Conjunctivitis
- Eyelid erythema
- Ocular discharge
- Ocular hypertension
- Ocular irritation
- Ocular irritation
- Ocular pain
Rare or Very Rare
- Eyelid edema
- Foreign body sensation of eye
Precautions
No enhanced messaging available.
No enhanced messaging available.
Animal reproduction studies using systemic tobramycin dosages up to 33 times the usual human systemic dosage have not revealed evidence of impaired fertility or harm to the fetus.
There are no controlled studies to date using tobramycin ophthalmic preparations in pregnant women.
Tobramycin ophthalmic ointment and ophthalmic solution should be used during pregnancy only if clearly needed.
Fixed-combination ophthalmic preparations containing tobramycin and a corticosteroid (i.e., dexamethasone or loteprednol etabonate) should be used during pregnancy only if potential benefits justify potential risks to the fetus.
A decision should be made whether to discontinue nursing or discontinue tobramycin ophthalmic preparations, taking into account the importance of the drug to the woman.
The manufacturers state that caution is advised if fixed-combination ophthalmic preparations containing tobramycin and a corticosteroid are used in nursing women.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Ocular inflammation | ||
| H57.8 | ICD10CM | Other specified disorders of eye and adnexa |
| T86.840 | ICD10CM | Corneal transplant rejection |
| T86.8401 | ICD10CM | Corneal transplant rejection, right eye |
| T86.8402 | ICD10CM | Corneal transplant rejection, left eye |
| T86.8403 | ICD10CM | Corneal transplant rejection, bilateral |
| T86.8409 | ICD10CM | Corneal transplant rejection, unspecified eye |
| T86.841 | ICD10CM | Corneal transplant failure |
| T86.8411 | ICD10CM | Corneal transplant failure, right eye |
| T86.8412 | ICD10CM | Corneal transplant failure, left eye |
| T86.8413 | ICD10CM | Corneal transplant failure, bilateral |
| T86.8419 | ICD10CM | Corneal transplant failure, unspecified eye |
| T86.842 | ICD10CM | Corneal transplant infection |
| T86.8421 | ICD10CM | Corneal transplant infection, right eye |
| T86.8422 | ICD10CM | Corneal transplant infection, left eye |
| T86.8423 | ICD10CM | Corneal transplant infection, bilateral |
| T86.8429 | ICD10CM | Corneal transplant infection, unspecified eye |
| Superficial ocular infection | ||
| H10.0 | ICD10CM | Mucopurulent conjunctivitis |
| H10.01 | ICD10CM | Acute follicular conjunctivitis |
| H10.011 | ICD10CM | Acute follicular conjunctivitis, right eye |
| H10.012 | ICD10CM | Acute follicular conjunctivitis, left eye |
| H10.013 | ICD10CM | Acute follicular conjunctivitis, bilateral |
| H10.019 | ICD10CM | Acute follicular conjunctivitis, unspecified eye |
| H10.02 | ICD10CM | Other mucopurulent conjunctivitis |
| H10.021 | ICD10CM | Other mucopurulent conjunctivitis, right eye |
| H10.022 | ICD10CM | Other mucopurulent conjunctivitis, left eye |
| H10.023 | ICD10CM | Other mucopurulent conjunctivitis, bilateral |
| H10.029 | ICD10CM | Other mucopurulent conjunctivitis, unspecified eye |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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