Methsuximide (methsuximide)
Anticonvulsants Oral Capsule
Last reviewed · Source: First Databank (FDB) drug data
Overview
Methsuximide is a succinimide-derivative anticonvulsant.
Methsuximide is used in the management of absence (petit mal) seizures. In contrast to ethosuximide and phensuximide (no longer commercially available in the US), methsuximide does not usually precipitate tonic-clonic (grand mal) seizures and therefore may be especially useful in conjunction with other anticonvulsants such as phenytoin or phenobarbital in the management of combined absence and tonic-clonic seizures. Methsuximide may also be useful alone or in conjunction with other anticonvulsants such as phenytoin or phenobarbital in the management of some cases of partial seizures with complex symptomatology (psychomotor seizures).
Methsuximide is generally regarded as a drug to be used when other medications have failed to effectively control absence seizures or partial seizures with complex symptomatology.
Generic name: methsuximide
Pronunciation: (meth-SUX-eh-mide)
Drug class: Anticonvulsants
Therapeutic class: Central Nervous System Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Methsuximide
Indications
The following indications are listed for Methsuximide:
- Absence Epilepsy
- Epilepsy
Also known as: Absence Epilepsy Simple, Absence Seizures, Epileptic Disorder, Minor Epilepsy, Petit Mal Epilepsy.
Dosing
Dosage must be carefully and slowly adjusted according to individual requirements and response. Methsuximide should be withdrawn or dosage reduced slowly to avoid precipitating seizures or absence status.
The usual initial dosage of methsuximide for adults or children is 300 mg daily for the first week. If necessary, daily dosage may be increased by 300-mg increments at weekly intervals thereafter up to a maximum daily dosage of 1.2 g, administered in divided doses. Some clinicians report that the usual maintenance dosage is 10 mg/kg or 600 mg/m2 daily.
Methsuximide is administered orally.
Patients who are currently receiving or beginning therapy with methsuximide and/or any other anticonvulsant should be closely monitored for notable changes in behavior that could indicate the emergence or worsening of suicidal thoughts or behavior or depression. (See Cautions: Precautions and Contraindications, in the Anticonvulsants General Statement 28:12.)
| Drug label | Dosing type | Instructions |
|---|---|---|
| Methsuximide 300 Mg Capsule | Maintenance | Take 1 capsule (300 mg) by oral route once daily. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Methsuximide 300 Mg Capsule | Maintenance | Take 1 capsule (300 mg) by oral route once daily. |
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
- Acute intermittent porphyria
- Disease of liver
- Suicidal ideation
- Aggressive behavior
- Depression
- Kidney disease with reduction in glomerular filtration rate (GFr)
- Neutropenic disorder
- Systemic lupus erythematosus
Adverse reactions
There is no enhanced messaging for this drug.
Less Frequent
- Aggressive behavior
- Concentration difficulty
- Depression
- Night terror
Rare or Very Rare
- Abnormal hepatic function tests
- Accidental fall
- Agranulocytosis
- Allergic dermatitis
- Aplastic anemia
- Blood dyscrasias
- DRESS syndrome
- Drug-induced psychosis
- Eosinophilia
- Euphoria
- Gingival hyperplasia
- Hematuria
- Hepatitis
- Hypersensitivity drug reaction
- Lethargy
- Leukopenia
- Lymphadenopathy
- Multiple organ failure
- Myocarditis
- Myopia
- Myositis
- Nephritis
- Neutropenic disorder
- Pancytopenia
- Pruritus of skin
- Skin rash
- Stevens-johnson syndrome
- Suicidal ideation
- Systemic lupus erythematosus
- Thrombocytopenic disorder
- Tonic clonic seizure
More Frequent
- Abdominal pain with cramps
- Anorexia
- Ataxia
- Dizziness
- Drowsy
- Headache disorder
- Hiccups
- Nausea
- Vomiting
Less Frequent
- Diarrhea
- Fatigue
- General weakness
- Increased libido
- Irritability
- Weight loss
Rare or Very Rare
- Abnormal vaginal bleeding
- Behavioral disorders
- Fever
- Hirsutism
- Hyperkinesis
- Sleep disorder
- Tongue swelling
- Urticaria
Precautions
No enhanced messaging available.
No enhanced messaging available.
Safe use of methsuximide during pregnancy has not been established. (See Cautions: Pregnancy and Lactation, in the Anticonvulsants General Statement 28:12.)
Safe use of methsuximide during lactation has not been established. (See Cautions: Pregnancy and Lactation, in the Anticonvulsants General Statement 28:12.)
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Absence epilepsy | ||
| G40.A | ICD10CM | Absence epileptic syndrome |
| G40.A0 | ICD10CM | Absence epileptic syndrome, not intractable |
| G40.A09 | ICD10CM | Absence epileptic syndrome, not intractable, without status epilepticus |
| G40.A1 | ICD10CM | Absence epileptic syndrome, intractable |
| G40.A19 | ICD10CM | Absence epileptic syndrome, intractable, without status epilepticus |
| Epilepsy | ||
| E88.42 | ICD10CM | MERRF syndrome |
| G40 | ICD10CM | Epilepsy and recurrent seizures |
| G40.0 | ICD10CM | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset |
| G40.00 | ICD10CM | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable |
| G40.001 | ICD10CM | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable, with status epilepticus |
| G40.009 | ICD10CM | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, not intractable, without status epilepticus |
| G40.01 | ICD10CM | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable |
| G40.011 | ICD10CM | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable, with status epilepticus |
| G40.019 | ICD10CM | Localization-related (focal) (partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset, intractable, without status epilepticus |
| G40.1 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures |
| G40.10 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable |
| G40.101 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable, with status epilepticus |
| G40.109 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, not intractable, without status epilepticus |
| G40.11 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable |
| G40.111 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable, with status epilepticus |
| G40.119 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures, intractable, without status epilepticus |
| G40.2 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures |
| G40.20 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable |
| G40.201 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable, with status epilepticus |
| G40.209 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, not intractable, without status epilepticus |
| G40.21 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable |
| G40.211 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable, with status epilepticus |
| G40.219 | ICD10CM | Localization-related (focal) (partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures, intractable, without status epilepticus |
| G40.3 | ICD10CM | Generalized idiopathic epilepsy and epileptic syndromes |
| G40.30 | ICD10CM | Generalized idiopathic epilepsy and epileptic syndromes, not intractable |
| G40.301 | ICD10CM | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, with status epilepticus |
| G40.309 | ICD10CM | Generalized idiopathic epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.31 | ICD10CM | Generalized idiopathic epilepsy and epileptic syndromes, intractable |
| G40.311 | ICD10CM | Generalized idiopathic epilepsy and epileptic syndromes, intractable, with status epilepticus |
| G40.319 | ICD10CM | Generalized idiopathic epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.4 | ICD10CM | Other generalized epilepsy and epileptic syndromes |
| G40.40 | ICD10CM | Other generalized epilepsy and epileptic syndromes, not intractable |
| G40.401 | ICD10CM | Other generalized epilepsy and epileptic syndromes, not intractable, with status epilepticus |
| G40.409 | ICD10CM | Other generalized epilepsy and epileptic syndromes, not intractable, without status epilepticus |
| G40.41 | ICD10CM | Other generalized epilepsy and epileptic syndromes, intractable |
| G40.411 | ICD10CM | Other generalized epilepsy and epileptic syndromes, intractable, with status epilepticus |
| G40.419 | ICD10CM | Other generalized epilepsy and epileptic syndromes, intractable, without status epilepticus |
| G40.42 | ICD10CM | Cyclin-dependent kinase-like 5 deficiency disorder |
| G40.5 | ICD10CM | Epileptic seizures related to external causes |
| G40.50 | ICD10CM | Epileptic seizures related to external causes, not intractable |
| G40.501 | ICD10CM | Epileptic seizures related to external causes, not intractable, with status epilepticus |
| G40.509 | ICD10CM | Epileptic seizures related to external causes, not intractable, without status epilepticus |
| G40.8 | ICD10CM | Other epilepsy and recurrent seizures |
| G40.80 | ICD10CM | Other epilepsy |
| G40.801 | ICD10CM | Other epilepsy, not intractable, with status epilepticus |
| G40.802 | ICD10CM | Other epilepsy, not intractable, without status epilepticus |
| G40.803 | ICD10CM | Other epilepsy, intractable, with status epilepticus |
| G40.804 | ICD10CM | Other epilepsy, intractable, without status epilepticus |
| G40.81 | ICD10CM | Lennox-gastaut syndrome |
| G40.811 | ICD10CM | Lennox-gastaut syndrome, not intractable, with status epilepticus |
| G40.812 | ICD10CM | Lennox-gastaut syndrome, not intractable, without status epilepticus |
| G40.813 | ICD10CM | Lennox-gastaut syndrome, intractable, with status epilepticus |
| G40.814 | ICD10CM | Lennox-gastaut syndrome, intractable, without status epilepticus |
| G40.82 | ICD10CM | Epileptic spasms |
| G40.821 | ICD10CM | Epileptic spasms, not intractable, with status epilepticus |
| G40.822 | ICD10CM | Epileptic spasms, not intractable, without status epilepticus |
| G40.823 | ICD10CM | Epileptic spasms, intractable, with status epilepticus |
| G40.824 | ICD10CM | Epileptic spasms, intractable, without status epilepticus |
| G40.83 | ICD10CM | Dravet syndrome |
| G40.833 | ICD10CM | Dravet syndrome, intractable, with status epilepticus |
| G40.834 | ICD10CM | Dravet syndrome, intractable, without status epilepticus |
| G40.84 | ICD10CM | KCNq2-related epilepsy |
| G40.841 | ICD10CM | KCNq2-related epilepsy, not intractable, with status epilepticus |
| G40.842 | ICD10CM | KCNq2-related epilepsy, not intractable, without status epilepticus |
| G40.843 | ICD10CM | KCNq2-related epilepsy, intractable, with status epilepticus |
| G40.844 | ICD10CM | KCNq2-related epilepsy, intractable, without status epilepticus |
| G40.89 | ICD10CM | Other seizures |
| G40.9 | ICD10CM | Epilepsy, unspecified |
| G40.90 | ICD10CM | Epilepsy, unspecified, not intractable |
| G40.901 | ICD10CM | Epilepsy, unspecified, not intractable, with status epilepticus |
| G40.909 | ICD10CM | Epilepsy, unspecified, not intractable, without status epilepticus |
| G40.91 | ICD10CM | Epilepsy, unspecified, intractable |
| G40.911 | ICD10CM | Epilepsy, unspecified, intractable, with status epilepticus |
| G40.919 | ICD10CM | Epilepsy, unspecified, intractable, without status epilepticus |
| G40.A | ICD10CM | Absence epileptic syndrome |
| G40.A0 | ICD10CM | Absence epileptic syndrome, not intractable |
| G40.A01 | ICD10CM | Absence epileptic syndrome, not intractable, with status epilepticus |
| G40.A09 | ICD10CM | Absence epileptic syndrome, not intractable, without status epilepticus |
| G40.A1 | ICD10CM | Absence epileptic syndrome, intractable |
| G40.A11 | ICD10CM | Absence epileptic syndrome, intractable, with status epilepticus |
| G40.A19 | ICD10CM | Absence epileptic syndrome, intractable, without status epilepticus |
| G40.B | ICD10CM | Juvenile myoclonic epilepsy [impulsive petit mal] |
| G40.B0 | ICD10CM | Juvenile myoclonic epilepsy, not intractable |
| G40.B01 | ICD10CM | Juvenile myoclonic epilepsy, not intractable, with status epilepticus |
| G40.B09 | ICD10CM | Juvenile myoclonic epilepsy, not intractable, without status epilepticus |
| G40.B1 | ICD10CM | Juvenile myoclonic epilepsy, intractable |
| G40.B11 | ICD10CM | Juvenile myoclonic epilepsy, intractable, with status epilepticus |
| G40.B19 | ICD10CM | Juvenile myoclonic epilepsy, intractable, without status epilepticus |
| G40.C | ICD10CM | Lafora progressive myoclonus epilepsy |
| G40.C0 | ICD10CM | Lafora progressive myoclonus epilepsy, not intractable |
| G40.C01 | ICD10CM | Lafora progressive myoclonus epilepsy, not intractable, with status epilepticus |
| G40.C09 | ICD10CM | Lafora progressive myoclonus epilepsy, not intractable, without status epilepticus |
| G40.C1 | ICD10CM | Lafora progressive myoclonus epilepsy, intractable |
| G40.C11 | ICD10CM | Lafora progressive myoclonus epilepsy, intractable, with status epilepticus |
| G40.C19 | ICD10CM | Lafora progressive myoclonus epilepsy, intractable, without status epilepticus |
ICD code information from First Databank (FDB).
Formulary status
Search health-plan coverage for this drug by ZIP code.
Choose the first character of a health plan name.
Last reviewed · Source: First Databank (FDB) drug data
On this page
Actions
Sign in to save favorites
Saving this drug requires a free Physicians Office Resource account.