Stendra (avanafil)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Avanafil, a selective phosphodiesterase (PDE) type 5 inhibitor, is a vasodilating agent.
Avanafil is a selective inhibitor of phosphodiesterases (PDEs) that is highly selective for PDE type 5, the principal isoenzyme of PDE involved in the metabolism of cyclic guanosine monophosphate (cGMP) to GMP in the corpora cavernosa of the penis. In vitro, avanafil does not substantially inhibit other PDE isoenzymes.
During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpora cavernosa. Nitric oxide activates the enzyme guanylate cyclase, which stimulates the synthesis of cGMP. cGMP produces smooth muscle relaxation and increased blood flow into the corpora cavernosa. By selectively inhibiting PDE type 5, avanafil increases cGMP concentrations in the corpora cavernosa of the penis, resulting in nitric oxide-stimulated vascular relaxation.
Avanafil has no effect on erectile function in the absence of sexual stimulation.
Avanafil produces a modest reduction in the maximum supine systolic/diastolic blood pressure (average of about 5/4 mm Hg) in healthy individuals.
USES: Avanafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, avanafil works by increasing blood flow to the penis to help a man get and keep an erection. This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis).
Using an effective barrier method (latex or polyurethane condom/dental dams) during sexual activity will help to decrease your risk of infection.
Generic name: avanafil
Pronunciation: (a-VAN-a-fil)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
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Indications
The following indications are listed for Stendra:
- Erectile Dysfunction
Also known as: Impotency.
Dosing
No dosing information is available for this tab.
Avanafil is administered orally without regard to meals. Administration of the drug with a high-fat meal may delay the onset of action, but dose adjustments do not appear to be necessary.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
Concomitant use of any form of organic nitrate (e.g., nitrates, nitrites, nitric oxide donors), either regularly or intermittently. (See Cautions, in Sildenafil Citrate 24:08.12.)
Known hypersensitivity to avanafil or any ingredient in the formulation.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
Common adverse effects reported in at least 2% of patients receiving avanafil for the treatment of ED in clinical trials include headache, flushing, nasal congestion, nasopharyngitis, and back pain.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
Safety and efficacy of avanafil have not been established in individuals younger than 18 years of age, and the drug is not indicated for use in pediatric patients.
Category C. (See Users Guide.) The manufacturer states that avanafil is not indicated for use in women.
No enhanced messaging available.
Avanafil dose adjustment based solely on age is not necessary in geriatric patients.
Approximately 23% of men in clinical studies of avanafil were 65 years of age or older; no differences in efficacy or safety were observed in geriatric men (older than 65 years of age) compared with younger men. However, the possibility of greater sensitivity in some geriatric individuals cannot be ruled out. (See Geriatric Patients under Dosage and Administration: Special Populations.)
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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