Amiloride-Hydrochlorothiazide (amiloride HCl/hydrochlorothiazide)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Amiloride hydrochloride is a potassium-sparing diuretic.
Hydrochlorothiazide is a thiazide diuretic and antihypertensive agent.
USES: This medication is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen. This drug is also used to treat high blood pressure.
Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications, amiloride and hydrochlorothiazide. Both medications are "water pills" (diuretics) that cause you to make more urine.
This helps your body get rid of extra water and salt. Amiloride also helps to treat or prevent low blood potassium levels.
Generic name: amiloride HCl/hydrochlorothiazide
Pronunciation: (a-MIL-oh-ride/HYE-droe-KLOR-oh-THYE-a-zide)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Amiloride-Hydrochlorothiazide
Indications
The following indications are listed for Amiloride-Hydrochlorothiazide:
- Edema
- Hypertension
Also known as: Edematous Sodium Retaining Conditions, Elevated Blood Pressure, Essential Hypertension, Hyperpiesia, Hyperpiesis, Hypertensive Disorder, Systemic Arterial Hypertension.
Dosing
Dosage of amiloride hydrochloride should be individualized according to patient requirements and response.
Dosage of hydrochlorothiazide should be individualized according to the patient's requirements and response. The lowest dosage necessary to produce the desired clinical effect should be used. If hydrochlorothiazide is added to the regimen of a patient stabilized on a potent hypotensive agent, dosage of the hypotensive agent should initially be reduced to avoid the possibility of severe hypotension.
Amiloride hydrochloride is administered orally, preferably with food to decrease adverse GI effects. Although amiloride hydrochloride may be used alone, the drug is generally administered concomitantly with a kaliuretic diuretic.
Hydrochlorothiazide is administered orally.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Amiloride has been shown to cross the placenta in animals. Following administration of a single 10-mg/kg oral dose of radiolabeled amiloride to rats, traces of drug crossed the placenta. Reproduction studies in rabbits and mice using oral amiloride doses up to 20 and 25 times the maximum daily human dose, respectively, have not revealed evidence of harm to the fetus. Reproduction studies in rats and rabbits using amiloride dosages up to 8 mg/kg daily have revealed evidence of reduced maternal growth rate in rats, maternal weight loss in rabbits, and adverse effects on growth and survival of rat offspring. There are no adequate and controlled studies to date using amiloride in pregnant women, and the drug should be used during pregnancy only when clearly needed.
It is not known if amiloride is distributed into human milk; however, amiloride is distributed into the milk of lactating animals. Because of the potential for serious adverse reactions from amiloride in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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