Miochol-E (acetylcholine chloride)
Parasympathetic Miotics Intraocular Kit
Last reviewed · Source: First Databank (FDB) drug data
Overview
Acetylcholine, a direct-acting parasympathomimetic agent, is a miotic.
Generic name: acetylcholine chloride
Drug class: Parasympathetic Miotics
Therapeutic class: Ophthalmic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Miochol-E
Indications
The following indications are listed for Miochol-E:
- Miosis Induction During Ocular Surgery
Also known as: Induce Pupil Constriction During Ocular Procedure, Induction Of Miosis During Eye Procedure.
Dosing
The usual dose of acetylcholine chloride to produce miosis during surgery is 0.5-2 mL of the 1% injection (5-20 mg) instilled into the anterior chamber before or after securing one or more sutures. To maintain miosis, 2% pilocarpine or 0.25% physostigmine solution may be applied topically immediately after surgery before application of the dressing.
Acetylcholine chloride is administered only in solution by instillation into the anterior chamber of the eye to produce miosis during ophthalmic surgery. The drug should be reconstituted immediately before use by removing the protective cap from the commercially available two-chambered vial, giving the plunger-stopper a quarter turn and pressing to force the solvent and center rubber plug into the lower chamber, and shaking the vial gently to dissolve the solid. If the rubber plug cannot be forced down or is already in the lower chamber, or if the reconstituted solution is discolored or contains a precipitate, the vial should not be used. Reconstitution produces 2 mL of a solution containing 1% (1:100) acetylcholine chloride and 2.8% mannitol. After cleansing the plunger-stopper with 70% alcohol or other suitable germicide, the appropriate dose of acetylcholine chloride is drawn into a dry, sterile syringe with an 18- to 20-gauge needle; the needle is then replaced with a suitable atraumatic cannula for intraocular irrigation. Instillation should be gentle and parallel to the iris face and tangential to the pupil border; flushing of the solution from the anterior chamber after miosis occurs is not necessary because of the short duration of action of the drug. In cataract surgery, acetylcholine should be used only after delivery of the lens.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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- Lactation
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
Rare or Very Rare
- Bradycardia
- Corneal nebula
- Dyspnea
- Hypotension
Less Frequent
- Corneal edema
Rare or Very Rare
- Flushing
- Hyperhidrosis
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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