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Cefazolin In Dextrose (Iso-Os) (cefazolin sodium/dextrose, iso-osmotic)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Cefazolin sodium is a semisynthetic, first generation cephalosporin antibiotic.

USES: Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. This medication is known as a cephalosporin antibiotic.

It works by stopping the growth of bacteria.

Generic name: cefazolin sodium/dextrose, iso-osmotic
Pronunciation: (sef-A-zoe-lin)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Cefazolin In Dextrose (Iso-Os):

  • Bacterial Endocarditis
  • Bacterial Pneumonia
  • Bacterial Sepsis
  • Bacterial Urinary Tract Infection
  • Biliary Tract Infection
  • Bone Infection
  • Genitourinary Tract Infections
  • Infectious Disorder Of Joint
  • Lower Respiratory Infection
  • Prevention Of Perioperative Infection
  • Skin And Skin Structure Infection
  • Staphylococcal Pneumonia
  • Staphylococcus Aureus Endocarditis
  • Streptococcal Endocarditis
  • Streptococcal Pneumonia

Also known as: Bacteremia With Sepsis, Bacterial Septicemia, Endocarditis Due To S. Aureus, Endocarditis Due To Staphylococcus Aureus, Endocarditis Due To Streptococcus, Genitourinary Infection, Genitourinary Tract Infection, Infection Of Skin And/Or Subcutaneous Tissue, Infective Cholangitis, Joint Infection, Lower Respiratory Tract Infection, Perioperative Infection Prophylaxis, Pneumonia Due To Staphylococcus Species, Pneumonia Due To Staphylococcus Spp., Pneumonia Due To Streptococcus Species, Pneumonia Due To Streptococcus Spp., Skin And Soft Tissue Skin Infection.

Dosing

Dosage of cefazolin sodium is expressed in terms of cefazolin and is identical for IM or IV administration.

To avoid unintentional overdosage, the commercially available Duplex(R) drug delivery system containing cefazolin and dextrose injection and the commercially available frozen premixed cefazolin injection in dextrose should not be used in patients who require less than the entire 1- or 2-g dose in the container.

In patients with impaired renal function, doses and/or frequency of administration of cefazolin must be modified in response to the degree of impairment, severity of the infection, susceptibility of the causative organism, and serum concentrations of the drug.

The manufacturers recommend an initial loading dose appropriate for the severity of the infection followed by dosage based on the degree of renal impairment. (See Table 1 and Table 2.)

Table 1. Dosage for Adults with Renal Impairment

Creatinine Clearance (mL/minute) Dosage After Initial Loading Dose 35-54 Full doses at intervals >=8 hours 11-34 50% of usual dose every 12 hours <=10 50% of usual dose every 18-24 hours

Table 2. Dosage for Children Older than 1 Month of Age with Renal Impairment

Creatinine Clearance (mL/minute) Dosage After Initial Loading Dose 40-70 60% of usual daily dosage in divided doses every 12 hours 20-40 25% of usual daily dosage in divided doses every 12 hours 5-20 10% of usual daily dosage once every 24 hours

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

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Adverse reactions

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Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data