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Neomycin Sulfate (neomycin sulfate)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Neomycin is an aminoglycoside antibiotic.

USES: This medication is used to decrease the risk of infection after certain intestinal surgeries. Neomycin belongs to a class of drugs known as aminoglycoside antibiotics. It works by stopping the growth of bacteria in the intestines.

Neomycin may also be used along with a special diet to treat a certain serious brain problem (hepatic encephalopathy). This condition is caused by too much of a certain natural substance (ammonia). Normally, the liver gets rid of ammonia, but liver disease can cause too much ammonia to build up in the body.

This medication helps treat encephalopathy by killing certain intestinal bacteria that make ammonia. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu).

Using any antibiotic when it is not needed can cause it to not work for future infections.

Generic name: neomycin sulfate
Pronunciation: (nee-oh-MY-sin)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Neomycin Sulfate:

  • Hepatic Coma
  • Hepatic Encephalopathy
  • Preoperative Bowel Preparation

Also known as: Portal Systemic Encephalopathy.

Dosing

Potency of neomycin sulfate has been expressed both in terms of the base and the salt, but generally is expressed in terms of the sulfate.

To minimize the risk of toxicity, the lowest possible dosage and shortest duration of therapy that is effective should be used. A treatment duration longer than 2 weeks is not recommended. If treatment is prolonged, serum neomycin concentrations should be monitored to avoid potentially toxic concentrations and the benefits of the drug to the patient should be weighed against the risks of nephrotoxicity, permanent ototoxicity, and neuromuscular blockade.

Dosage of neomycin sulfate should be reduced or the drug discontinued in patients with renal impairment. Some clinicians recommend the neomycin doses be given every 6 hours in patients with glomerular filtration rates (GFRs) greater than 50 mL/minute, every 12-18 hours in those with GFRs 10-50 mL/minute, and every 18-24 hours in those with GFRs less than 10 mL/minute.

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

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Adverse reactions

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Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data