Adrenal Steroid Inhibitors

Adrenal steroid inhibitors are a therapeutic class of pharmacologic agents, often designated in clinical compendia as adrenal steroidogenesis or cortisol synthesis inhibitors, that suppress the enzymatic production of adrenocortical hormones These agents primarily function by blocking critical cytochrome P450 enzymes within the adrenal cortex—such as 11-beta-hydroxylase or 17-alpha-hydroxylase—thereby halting downstream production of cortisol and other corticosteroids Representative drugs within...

Adrenal steroid inhibitors are a therapeutic class of pharmacologic agents, often designated in clinical compendia as adrenal steroidogenesis or cortisol synthesis inhibitors, that suppress the enzymatic production of adrenocortical hormones

These agents primarily function by blocking critical cytochrome P450 enzymes within the adrenal cortex—such as 11-beta-hydroxylase or 17-alpha-hydroxylase—thereby halting downstream production of cortisol and other corticosteroids Therapeutically, this class is predominantly indicated for the medical management of endogenous hypercortisolemia in Cushing disease or Cushing syndrome, and selected agents may also be utilized in adrenal malignancies or diagnostic endocrine testing

Therapeutically, this class is predominantly indicated for the medical management of endogenous hypercortisolemia in Cushing disease or Cushing syndrome, and selected agents may also be utilized in adrenal malignancies or diagnostic endocrine testing

Representative drugs within this category include osilodrostat, metyrapone, and ketoconazole