XPOVIO (selinexor)
ANTINEOPLASTIC-SELECTIVE INHIBITORS OF NUCLEAR EXPORT(SINE) · MULTIPLE MYELOMA
KARYOPHARM THER
Drug class
Antineoplastic-Selective Inhibitors of Nuclear Export(SINE)
Antineoplastic selective inhibitors of nuclear export (SINE) are a targeted class of anticancer agents that block nucleocytoplasmic transport in malignant cells. Read more about Antineoplastic-Selective Inhibitors of Nuclear Export(SINE)
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Antineoplastic selective inhibitors of nuclear export (SINE) are a targeted class of anticancer agents that block nucleocytoplasmic transport in malignant cells.
They function primarily by binding to exportin 1 (XPO1, also known as CRM1), preventing the export of tumor suppressor proteins and growth regulatory factors out of the nucleus.
This targeted nuclear retention restores natural tumor-suppressive pathways, resulting in cell cycle arrest and selective apoptosis of neoplastic cells.
Clinically, representative agents such as selinexor are primarily indicated for hematologic malignancies, most notably relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
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nih.gov
Antineoplastic selective inhibitors of nuclear export (SINE) are a targeted class of anticancer agents that block nucleocytoplasmic transport in malignant cells They function primarily by binding to exportin 1 (XPO1, also known as CRM1), preventing the export of tumor suppressor proteins and growth regulatory factors out of the nucleus
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mdpi.com
Antineoplastic selective inhibitors of nuclear export (SINE) are a targeted class of anticancer agents that block nucleocytoplasmic transport in malignant cells They function primarily by binding to exportin 1 (XPO1, also known as CRM1), preventing the export of tumor suppressor proteins and growth regulatory factors out of the nucleus Clinically, representative agents such as selinexor are primarily indicated for hematologic malignancies, most notably relapsed or refractory multiple myeloma and...
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cancer.gov
They function primarily by binding to exportin 1 (XPO1, also known as CRM1), preventing the export of tumor suppressor proteins and growth regulatory factors out of the nucleus This targeted nuclear retention restores natural tumor-suppressive pathways, resulting in cell cycle arrest and selective apoptosis of neoplastic cells
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johnshopkins.edu
This targeted nuclear retention restores natural tumor-suppressive pathways, resulting in cell cycle arrest and selective apoptosis of neoplastic cells
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rxlist.com
Clinically, representative agents such as selinexor are primarily indicated for hematologic malignancies, most notably relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma
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