Drug class

Dengue Vaccine

The dengue vaccine class comprises active immunizing biological agents developed to prevent dengue disease and reduce severe complications caused by the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, and DENV-4). Read more about Dengue Vaccine

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About Dengue Vaccine.

The dengue vaccine class comprises active immunizing biological agents developed to prevent dengue disease and reduce severe complications caused by the four dengue virus serotypes (DENV-1, DENV-2, DENV-3, and DENV-4).

Primarily formulated as live-attenuated tetravalent vaccines—such as chimeric yellow fever–dengue or recombinant attenuated dengue backbones—these agents elicit neutralizing antibody and cellular immune responses against all four viral serotypes.

Clinically, they are indicated for the prevention of symptomatic infection, hospitalization, and severe dengue manifestations, particularly dengue hemorrhagic fever and dengue shock syndrome, in populations living in or traveling to endemic regions.

Because serostatus significantly influences vaccine safety and efficacy profiles, use within this class often depends on prior exposure to minimize risks of vaccine-induced disease enhancement.