Drug class

Menopausal Symptoms Suppressant - Neurokinin Receptor Antago

The therapeutic class "Menopausal Symptoms Suppressant - Neurokinin Receptor Antagonist" comprises nonhormonal medications formulated to manage moderate to severe vasomotor symptoms, such as hot flashes and night sweats, associated with menopause. Read more about Menopausal Symptoms Suppressant - Neurokinin Receptor Antago

2 drugs in this class 2 manufacturers

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Drugs in Menopausal Symptoms Suppressant - Neurokinin Receptor Antago

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VEOZAH (fezolinetant)

MENOPAUSAL SYMPTOMS SUPPRESSANT - NEUROKININ RECEPTOR ANTAGO · VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
Astellas Pharma US

LYNKUET (elinzanetant)

MENOPAUSAL SYMPTOMS SUPPRESSANT - NEUROKININ RECEPTOR ANTAGO · VASOMOTOR SYMPTOMS ASSOCIATED WITH MENOPAUSE
Bayer HealthCare
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About Menopausal Symptoms Suppressant - Neurokinin Receptor Antago.

The therapeutic class "Menopausal Symptoms Suppressant - Neurokinin Receptor Antagonist" comprises nonhormonal medications formulated to manage moderate to severe vasomotor symptoms, such as hot flashes and night sweats, associated with menopause.

Agents in this class—most notably neurokinin 3 (NK3) or dual neurokinin 1 and 3 (NK1/3) receptor antagonists like fezolinetant and elinzanetant—work by competitively blocking neurokinin B signaling on kisspeptin/neurokinin B/dynorphin neurons within the hypothalamus.

By mitigating this receptor signaling, these drugs restore equilibrium to the hypothalamic thermoregulatory center disrupted by estrogen withdrawal.

Consequently, this class provides a targeted endocrine alternative for postmenopausal individuals experiencing disruptive vasomotor symptoms, particularly those with contraindications or preferences against hormone replacement therapy.