VORAXAZE (glucarpidase)
METHOTREXATE RESCUE AGENTS - CARBOXYPEPTIDASE G2 TYPE · METHOTREXATE TOXICITY
BTG INTERNATION
Drug class
Methotrexate Rescue Agents - Carboxypeptidase G2 Type
"Methotrexate Rescue Agents - Carboxypeptidase G2 Type" is a specialized formulary and compendial classification primarily represented by glucarpidase, a recombinant bacterial carboxypeptidase G2 enzyme. Read more about Methotrexate Rescue Agents - Carboxypeptidase G2 Type
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"Methotrexate Rescue Agents - Carboxypeptidase G2 Type" is a specialized formulary and compendial classification primarily represented by glucarpidase, a recombinant bacterial carboxypeptidase G2 enzyme.
Unlike folinic acid rescue agents that bypass folate pathway inhibition, this class functions by rapidly hydrolyzing extracellular methotrexate into the inactive metabolites glutamate and 2,4-diamino-N10-methylpteroic acid, establishing an alternative clearance pathway independent of renal excretion.
It is indicated in oncology to manage toxic plasma methotrexate concentrations in pediatric and adult cancer patients who develop delayed drug elimination resulting from methotrexate-induced acute renal impairment.
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wellfleetrx.com
"Methotrexate Rescue Agents - Carboxypeptidase G2 Type" is a specialized formulary and compendial classification primarily represented by glucarpidase, a recombinant bacterial carboxypeptidase G2 enzyme
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drugpatentwatch.com
"Methotrexate Rescue Agents - Carboxypeptidase G2 Type" is a specialized formulary and compendial classification primarily represented by glucarpidase, a recombinant bacterial carboxypeptidase G2 enzyme Unlike folinic acid rescue agents that bypass folate pathway inhibition, this class functions by rapidly hydrolyzing extracellular methotrexate into the inactive metabolites glutamate and 2,4-diamino-N10-methylpteroic acid, establishing an alternative clearance pathway independent of renal excret...
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nih.gov
Unlike folinic acid rescue agents that bypass folate pathway inhibition, this class functions by rapidly hydrolyzing extracellular methotrexate into the inactive metabolites glutamate and 2,4-diamino-N10-methylpteroic acid, establishing an alternative clearance pathway independent of renal excretion
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pdr.net
Unlike folinic acid rescue agents that bypass folate pathway inhibition, this class functions by rapidly hydrolyzing extracellular methotrexate into the inactive metabolites glutamate and 2,4-diamino-N10-methylpteroic acid, establishing an alternative clearance pathway independent of renal excretion
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aap.org
It is indicated in oncology to manage toxic plasma methotrexate concentrations in pediatric and adult cancer patients who develop delayed drug elimination resulting from methotrexate-induced acute renal impairment
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