Migraine Prevention Medications

Migraine prevention medications encompass a heterogeneous functional class of pharmacologic agents administered on an ongoing schedule to decrease the frequency, severity, and duration of migraine attacks rather than abort acute headache episodes

Migraine prevention medications encompass a heterogeneous functional class of pharmacologic agents administered on an ongoing schedule to decrease the frequency, severity, and duration of migraine attacks rather than abort acute headache episodes Because this grouping represents a broad clinical indication rather than a single chemical entity or single mechanism of action, it spans multiple drug families These include migraine-specific therapies—such as calcitonin gene-related peptide (CGRP) rec...

Because this grouping represents a broad clinical indication rather than a single chemical entity or single mechanism of action, it spans multiple drug families These agents are primarily indicated for the management and prophylaxis of episodic migraine and chronic migraine

These include migraine-specific therapies—such as calcitonin gene-related peptide (CGRP) receptor antagonists and monoclonal antibodies—as well as conventional non-specific agents like beta-blockers, anticonvulsants, tricyclic antidepressants, and neurotoxins

Collectively, their therapeutic role centers on modulating central and peripheral neurovascular pathways, inhibiting cortical hyperexcitability, or blocking nociceptive neuropeptide transmission

These agents are primarily indicated for the management and prophylaxis of episodic migraine and chronic migraine