Drug class
Pleuromutilin Derivatives, Topical
Topical pleuromutilin derivatives are a specialized subclass of semisynthetic antibacterial agents formulated for cutaneous application. Read more about Pleuromutilin Derivatives, Topical
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Drugs in Pleuromutilin Derivatives, Topical
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Topical pleuromutilin derivatives are a specialized subclass of semisynthetic antibacterial agents formulated for cutaneous application.
They exert their therapeutic effect by binding to the peptidyl transferase center of the bacterial 50S ribosomal subunit, thereby selectively inhibiting bacterial protein synthesis with minimal target-specific cross-resistance to other antimicrobial classes.
Represented clinically by retapamulin, this topical drug class is primarily used in dermatology to treat superficial bacterial skin infections, most notably impetigo and uncomplicated secondarily infected traumatic lesions caused by susceptible strains of *Staphylococcus aureus* and *Streptococcus pyogenes*.
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nih.gov
Topical pleuromutilin derivatives are a specialized subclass of semisynthetic antibacterial agents formulated for cutaneous application
-
nih.gov
Topical pleuromutilin derivatives are a specialized subclass of semisynthetic antibacterial agents formulated for cutaneous application They exert their therapeutic effect by binding to the peptidyl transferase center of the bacterial 50S ribosomal subunit, thereby selectively inhibiting bacterial protein synthesis with minimal target-specific cross-resistance to other antimicrobial classes Represented clinically by retapamulin, this topical drug class is primarily used in dermatology to treat s...
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acs.org
They exert their therapeutic effect by binding to the peptidyl transferase center of the bacterial 50S ribosomal subunit, thereby selectively inhibiting bacterial protein synthesis with minimal target-specific cross-resistance to other antimicrobial classes
-
nih.gov
They exert their therapeutic effect by binding to the peptidyl transferase center of the bacterial 50S ribosomal subunit, thereby selectively inhibiting bacterial protein synthesis with minimal target-specific cross-resistance to other antimicrobial classes
-
nih.gov
Represented clinically by retapamulin, this topical drug class is primarily used in dermatology to treat superficial bacterial skin infections, most notably impetigo and uncomplicated secondarily infected traumatic lesions caused by susceptible strains of *Staphylococcus aureus* and *Streptococcus pyogenes*
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