Amoxicillin (amoxicillin)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Amoxicillin is an aminopenicillin antibiotic that is structurally related to ampicillin.
Amoxicillin shares the uses of other aminopenicillins and is used principally for the treatment of infections caused by susceptible gram-negative bacteria (e.g., Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Salmonella). Amoxicillin also is used for the treatment of infections caused by susceptible gram-positive bacteria (e.g., Streptococcus pneumoniae, enterococci, nonpenicillinase-producing staphylococci, Listeria); however, like other aminopenicillins, amoxicillin generally should not be used for the treatment of streptococcal or staphylococcal infections when a natural penicillin would be effective.
Generic name: amoxicillin
Pronunciation: (a-MOX-i-SIL-in)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Amoxicillin
Indications
The following indications are listed for Amoxicillin:
- Acute Bacterial Otitis Media
- Acute Bacterial Sinusitis
- Acute Haemophilus Influenzae Bacterial Sinusitis
- Acute Streptococcus Pneumoniae Bacterial Sinusitis
- Chronic Bronchitis With Bacterial Exacerbation
- Duodenal Ulcer Due To H. Pylori
- E. Coli Genitourinary Tract Infection
- Enterococcus Genitourinary Tract Infection
- Genitourinary Tract Infection Due To Proteus
- Genitourinary Tract Infections
- H. Pylori Gastrointestinal Tract Infection
- Haemophilus Influenzae Chronic Bronchitis
- Haemophilus Influenzae Pharyngitis
- Haemophilus Influenzae Pneumonia
- Helicobacter Pylori Gastritis
- Lower Respiratory Infection
- Pharyngitis
- Pharyngitis Due To Streptococcus Pyogenes
- Pneumococcal Pneumonia
- Skin And Skin Structure E. Coli Infection
- Skin And Skin Structure Infection
- Skin And Skin Structure Streptococcus Infection
- Staphylococcal Pharyngitis
- Staphylococcal Tonsillitis
- Streptococcal Pneumonia
- Streptococcus Pneumoniae Chronic Bronchitis
- Tonsillitis Due To Haemophilus Influenzae
- Tonsillitis Due To Streptococcus Pyogenes
- Upper Respiratory Infection
Also known as: Acute Bacterial Exacerbation Of Chronic Bronchitis, Acute Sinusitis Due To Diplococcus Pneumoniae, Acute Sinusitis Due To Fraenkel's Pneumococcus, Acute Sinusitis Due To Fraenkel's Pneumonococcus, Acute Sinusitis Due To H. Flu, Acute Sinusitis Due To H. Influenzae, Acute Sinusitis Due To Haemophilus Influenzae, Acute Sinusitis Due To Hemophilus Influenzae, Acute Sinusitis Due To Influenza Bacillus, Acute Sinusitis Due To Pfeiffer's Bacillus, Acute Sinusitis Due To Pneumococcus, Acute Sinusitis Due To Streptococcus Pneumoniae, Acute Sinusitis From Fraenkel-Weichselbaum Pneumococcus, Acute Upper Respiratory Tract Infection, Acute Uri, Bacterial Exacerbation Of Chronic Bronchitis, Bacterial Otitis Media, Campylobacter Gastritis, Chronic Bronchitis Due To Diplococcus Pneumoniae, Chronic Bronchitis Due To Fraenkel's Pneumococcus, Chronic Bronchitis Due To H. Flu, Chronic Bronchitis Due To H. Influenzae, Chronic Bronchitis Due To Haemophilus Influenzae, Chronic Bronchitis Due To Hemophilus Influenzae, Chronic Bronchitis Due To Influenza Bacillus, Chronic Bronchitis Due To Pfeiffer's Bacillus, Chronic Bronchitis Due To Pneumococcus, Chronic Bronchitis Due To Pneumonococcus, Chronic Bronchitis Due To Streptococcus Pneumoniae, Du Due To H. Pylori, Duodenal Ulcer Due To Campylobacter Pylori, Duodenal Ulcer Due To Helicobacter Pylori, Epidemic Sore Throat, Fraenkel-Weichselbaum Pneumococcal Chronic Bronchitis, Genitourinary Infection, Genitourinary Infection Due To E. Coli, Genitourinary Infection Due To Enterococcus, Genitourinary Infection Due To Escherichia Coli, Genitourinary Infection Due To Proteus Species, Genitourinary Tract Infection, Genitourinary Tract Infection Due To E. Coli, Genitourinary Tract Infection Due To Enterococcus, Genitourinary Tract Infection Due To Proteus Species, H. Flu Pneumonia, H. Influenzae Pneumonia, H. Pylori Gastritis, Hemophilus Influenzae Pneumonia, Infection Of Skin And/Or Subcutaneous Tissue, Influenza Bacillus Pneumonia, Lower Respiratory Tract Infection, Pfeiffer's Bacillus Pneumonia, Pharyngitis Due To Group A Beta-Hemolytic Streptococci, Pharyngitis Due To Haemophilus Influenzae, Pharyngitis Due To Streptococcus Epidemicus, Pneumonia Due To Haemophilus Influenzae, Pneumonia Due To Streptococcus Pneumoniae, Pneumonia Due To Streptococcus Species, Pneumonia Due To Streptococcus Spp., Septic Sore Throat, Skin & Soft Tissue Streptococcal Infection, Skin & Soft Tissue Streptococcus Infection, Skin And Skin Soft Tissue Escherichia Coli Infection, Skin And Soft Tissue Skin Infection, Streptococcal Pharyngitis, Streptococcus Pyogenes Tonsillitis, Throat Inflammation, Tonsillitis Due To H. Flu, Tonsillitis Due To Hemophilus Influenzae, Tonsillitis Due To Influenza Bacillus, Tonsillitis Due To Pfeiffer's Bacillus, Tonsillitis Due To Staphylococcus Species, Tonsillitis Due To Staphylococcus Spp..
Dosing
Dosage of amoxicillin, which is available for oral use as the trihydrate, is expressed in terms of anhydrous amoxicillin.
In patients with renal impairment, doses and/or frequency of administration of amoxicillin should be modified in response to the degree of renal impairment, severity of the infection, and susceptibility of the causative organisms. The manufacturer states that adults with severe renal impairment and creatinine clearances less than 30 mL/minute should not receive the commercially available film-coated tablets containing 875 mg of amoxicillin. The recommended dosage of amoxicillin for adults with creatinine clearances of 10-30 mL/minute is 250 or 500 mg every 12 hours, depending on the severity of the infection, and the recommended dosage for adults with creatinine clearances less than 10 mL/minute is 250 or 500 mg every 24 hours, depending on the severity of the infection.
Patients undergoing hemodialysis should receive 250 or 500 mg of amoxicillin every 24 hours, depending on the severity of the infection, and should receive an additional dose of the drug during and after each dialysis period.
The manufacturer states that data are insufficient to recommend dosage for pediatric patients with renal impairment.
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Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Safe use of amoxicillin during pregnancy has not been definitely established. There are no adequate or controlled studies using aminopenicillins in pregnant women, and amoxicillin should be used during pregnancy only when clearly needed. However, amoxicillin has been administered to pregnant women without evidence of adverse effects to the fetus. In addition, amoxicillin is included in the US Centers For Disease Control and Prevention (CDC) recommendations for the treatment of chlamydial infections+ during pregnancy and included in CDC recommendations for the treatment of cutaneous anthrax+ or for postexposure prophylaxis+ following exposure to Bacillus anthracis spores.
Because amoxicillin is distributed into milk and may lead to sensitization of infants, the drug should be used with caution in nursing women. Because of its general safety in infants, CDC states that amoxicillin is an option for anti-infective prophylaxis in breast-feeding women when B. anthracis is known to be penicillin susceptible and there is no contraindication to maternal amoxicillin use.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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