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Atropine (atropine sulfate)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Atropine (dl-hyoscyamine), a naturally occurring tertiary amine antimuscarinic, is a mydriatic and cycloplegic.

Atropine sulfate ophthalmic preparations are used to produce mydriasis and cycloplegia for examination of the retina and optic disk and accurate measurement of refractive errors. However, because of the long duration of action of the drug, it is seldom, if ever, used for cycloplegic refraction in adults. In rare cases, topical ophthalmic atropine use may be necessary to achieve maximal cycloplegia in pediatric patients, but cyclopentolate is more frequently used.

Generic name: atropine sulfate
Pronunciation: (AT-roe-peen)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Atropine:

  • Cycloplegia
  • Mydriasis
  • Penalization Therapy For Unilateral Amblyopia

Dosing

To produce mydriasis and cycloplegia for refraction in adults, 1 drop of a 1% solution may be instilled onto the eye(s) 1 hour before the procedure. In children, the usual dosage for cycloplegic refraction is 1-2 drops of a 0.5% solution instilled onto the eye(s) twice daily for 1-3 days before the procedure (the 0.5% solution is no longer commercially available in the US). Alternatively, to produce mydriasis and cycloplegia for refraction in adults, 0.3-0.5 cm of a 1% ointment may be placed into the conjunctival sac 1-3 times daily. In children, the usual dosage for cycloplegic refraction is 0.3 cm of a 1% ointment placed into the conjunctival sac 3 times daily for 1-3 days before the procedure. If the ointment is used for refraction, the drug should be applied several hours before the procedure, since it may impair corneal transparency and prevent accurate measurement of refractive errors.

For pupillary dilation in the treatment of acute inflammatory conditions of the iris and uveal tract in adults (i.e., iridocyclitis, uveitis), 1 or 2 drops of a 0.5 or 1% solution may be instilled onto the eye(s) up to 4 times daily. In children, the usual dosage for the treatment of uveitis is 1 or 2 drops of a 0.5% solution up to 3 times daily. Alternatively, for pupillary dilation in the treatment of acute inflammatory conditions of the iris and uveal tract in adults and children, 0.3-0.5 cm of a 1% ointment may be placed into the conjunctival sac up to 3 times daily.

Drug interactions

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Contraindications

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Adverse reactions

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Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data