Avycaz (ceftazidime/avibactam sodium)

Ceftazidime and avibactam is a fixed combination containing a 4:1 ratio of ceftazidime to avibactam.

The ceftazidime component is provided as a mixture of ceftazidime pentahydrate and sodium carbonate (dosage of this component is expressed in terms of anhydrous ceftazidime); the avibactam component is provided as avibactam sodium (dosage of this component is expressed in terms of avibactam).

Dosage of the fixed combination of ceftazidime and avibactam is expressed in terms of the total of the ceftazidime and avibactam content.

Each single-dose vial of ceftazidime and avibactam contains a total of 2.5 g (i.e., 2 g of ceftazidime and 0.5 g of avibactam).

Dosage adjustments based solely on age are not needed when ceftazidime and avibactam is used in geriatric patients. However, because geriatric patients are more likely to have decreased renal function and because dosage of ceftazidime and avibactam needs to be adjusted based on renal impairment, dosage should be selected with caution and it may be useful to monitor renal function.

Dosage adjustments are not needed when ceftazidime and avibactam is used in adults with hepatic impairment.

Dosage of ceftazidime and avibactam must be adjusted in adults with creatinine clearances of 50 mL/minute or less, including those undergoing hemodialysis. (See Table 2.)

Creatinine clearance should be monitored at least once daily in patients with changing renal function and dosage of ceftazidime and avibactam adjusted accordingly.

Table 2. Ceftazidime and Avibactam Dosage for Adults with Renal Impairment

Estimated Creatinine Clearance Recommended Dosage (mL/minute) 31-50 1.25 g (ceftazidime 1 g and avibactam 0.25 g) every 8 hours 16-30 940 mg (ceftazidime 750 mg and avibactam 190 mg) every 12 hours 6-15 940 mg (ceftazidime 750 mg and avibactam 190 mg) every 24 hours <=5 940 mg (ceftazidime 750 mg and avibactam 190 mg) every 48 hours

On hemodialysis days, the dose should be administered after dialysis.

Ceftazidime and avibactam is administered by IV infusion.

No dosing information is available for this tab.

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There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

There are no contraindication contraindications for this drug.

There are no severe contraindications for this drug.

There are no moderate contraindications for this drug.

There is no enhanced messaging for this drug.

There are no severe adverse reactions for this drug.

There are no less severe adverse reactions for this drug.

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No enhanced messaging available.

Reproduction studies in mice and rats using ceftazidime dosages up to 40 times the usual human dose have not revealed evidence of harm to the fetus. Avibactam was not teratogenic in rats or rabbits. In rats, there was no evidence of embryofetal toxicity at an avibactam dosage of 1 g/kg daily (approximately 9 times the human dosage based on area under the concentration-time curve (AUC)) and no effects on pup growth and viability at a dosage of 825 mg/kg daily. In rabbits, there was no evidence of embryofetal toxicity at an avibactam dosage of 100 mg/kg, but increased implantation loss, lower mean fetal weights, delayed ossification of bones, and other anomalies were observed at higher dosages.

There are no adequate and controlled studies using ceftazidime and avibactam in pregnant women, and the drug should be used during pregnancy only if clearly needed.

Ceftazidime is distributed into human milk in low concentrations. It is not known whether avibactam is distributed into human milk. (See Pharmacokinetics: Distribution.)

Ceftazidime and avibactam should be used with caution in nursing women.

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