Calcium Pantothenate (calcium pantothenate)
Vitamin B-5 Oral Tablet
Last reviewed · Source: First Databank (FDB) drug data
Overview
Pantothenic acid is a water-soluble, B complex vitamin.
Pantothenic acid deficiency has rarely been identified in humans except in conjunction with deficiency of other B complex vitamins. Diagnosis of pantothenic acid deficiency is aided by a serum pantothenate concentration of less than 50 mcg/mL. Whenever possible, poor dietary habits should be corrected, and some clinicians recommend administration of multivitamin preparations containing pantothenic acid in patients with vitamin deficiencies since poor dietary habits may result in concurrent deficiencies. (See Multivitamins 88:28.) Some cases of peripheral neuritis, muscular cramps in the legs associated with pregnancy and alcoholism, burning feet syndrome, and glossitis refractory to other vitamin therapy have responded to pantothenic acid.
In one study, patients with celiac disease who did not respond to a gluten-free diet did improve when given pantothenate.
Generic name: calcium pantothenate
Drug class: Vitamin B-5
Therapeutic class: Electrolyte Balance-Nutritional Products
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Calcium Pantothenate
Indications
No indications are available for this drug.
Dosing
Each 10 mg of calcium pantothenate is equivalent to 9.2 mg of pantothenic acid.
Calcium pantothenate and pantothenic acid are usually administered orally; dexpanthenol is usually administered by IM injection, but may be given slowly by IV infusion. Dexpanthenol may also be administered topically in the form of a cream.
For IV infusion in adults, dexpanthenol injection has been added to a large volume parenteral solution of 5% dextrose or lactated Ringer's injection and infused slowly.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
On theoretical grounds, the manufacturers of dexpanthenol recommend that the drug not be given with or within 12 hours after administration of neostigmine or other parasympathomimetic drugs. Although the clinical importance has not been established, the miotic effects of anticholinesterase ophthalmic preparations (e.g., echothiophate iodide (no longer commercially available in the US), isoflurophate) reportedly may be potentiated by pantothenic acid. It has been reported that dexpanthenol prolonged the muscle relaxant effects of succinylcholine; however, a controlled trial failed to show this effect. The manufacturers recommend that dexpanthenol not be administered within 1 hour of succinylcholine. The manufacturers also warn that rare cases of allergic reactions of unknown cause have occurred during concomitant use of dexpanthenol injection and antibiotics, opiates, and barbiturates.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Animal reproduction studies have not been performed with dexpanthenol. It is not known whether dexpanthenol can cause fetal harm when administered to pregnant women. Dexpanthenol injection should be used during pregnancy only when clearly needed.
Since it is not known whether dexpanthenol is distributed into milk, dexpanthenol injection should be used with caution in nursing women.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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