Primsol (trimethoprim)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Trimethoprim, a dihydrofolate reductase inhibitor, is an antibacterial agent. (For information on the fixed combination containing trimethoprim and sulfamethoxazole, see Co-trimoxazole 8:12.20.)
USES: Trimethoprim is an antibiotic used to treat bacterial infections. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Generic name: trimethoprim
Pronunciation: (try-METH-oh-prim)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Primsol
Indications
The following indications are listed for Primsol:
- Acute Bacterial Otitis Media
- Bacterial Urinary Tract Infection
- E. Coli Urinary Tract Infection
- Enterobacter Cloacae Urinary Tract Infection
- Haemophilus Influenzae Acute Otitis Media
- Klebsiella Urinary Tract Infection
- Proteus Urinary Tract Infection
- Staphylococcus Saprophyticus Urinary Tract Infection
- Streptococcus Acute Otitis Media
Also known as: Acute Otitis Media Due To H. Flu, Acute Otitis Media Due To Haemophilus Influenzae, Acute Otitis Media Due To Hemophilus Influenzae, Acute Otitis Media Due To Influenza Bacillus, Acute Otitis Media Due To Pfeiffer's Bacillus, Acute Otitis Media Due To Streptococcus Species, Bacterial Otitis Media, E. Coli Uti, Klebsiella Uti, Urinary Tract Infection Due To Enterobacter Cloacae, Urinary Tract Infection Due To Escherichia Coli, Urinary Tract Infection Due To Klebsiella Species, Urinary Tract Infection Due To Proteus Species, Uti Due To Enterobacter Cloacae, Uti Due To Proteus Species, Uti Due To Staphylococcus Saprophyticus.
Dosing
If trimethoprim is used for treatment of acute, uncomplicated urinary tract infections in adults with creatinine clearances of 15-30 mL/minute, dosage of the drug should be reduced to 50 mg every 12 hours. The drug is not recommended in patients with creatinine clearances less than 15 mL/minute.
For information on dosage of the fixed combination containing trimethoprim and sulfamethoxazole, see Co-trimoxazole 8:12.20.
Trimethoprim is administered orally. Trimethoprim also is administered orally or IV as a fixed-combination preparation with sulfamethoxazole. (For information on the fixed combination containing trimethoprim and sulfamethoxazole, see Co-trimoxazole 8:12.20.)
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Trimethoprim has been shown to be teratogenic in rats when given in doses 40 times the usual human dose; in rabbits, an overall increase in fetal loss was associated with trimethoprim doses 6 times the usual human dose. Although there are no adequate and controlled studies to date using trimethoprim in humans, a retrospective study that reported the outcome of 186 pregnancies suggested that the incidence of congenital abnormalities in those who received the fixed combination containing trimethoprim and sulfamethoxazole (co-trimoxazole) was similar to that in those who received a placebo. Because trimethoprim may interfere with folic acid metabolism, the drug should be used during pregnancy only when potential benefits justify possible risks to the fetus.
Trimethoprim is distributed into milk. Because trimethoprim may interfere with folic acid metabolism, the drug should be used with caution in nursing women.
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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