Nasal Allergy (triamcinolone acetonide)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Triamcinolone acetonide is a synthetic corticosteroid.
Triamcinolone acetonide is a synthetic glucocorticoid. In animals, triamcinolone acetonide has relatively little mineralocorticoid activity; as a glucocorticoid, the drug is about 8 times more potent than prednisone.
Systemic absorption of triamcinolone acetonide has been shown to be minimal following intranasal administration of the drug. Following intranasal administration of a single 220-mcg dose of triamcinolone acetonide as an aqueous suspension aerosol, mean peak plasma concentrations of about 0.5 ng/mL (range: 0.1-1 ng/mL) were achieved at 1.5 hours following administration.
USES: Triamcinolone is used to prevent and treat seasonal and year-round allergy symptoms (such as stuffy/runny nose, itchy eyes/nose/throat, sneezing). Triamcinolone belongs to a class of drugs known as corticosteroids. It works by reducing swelling (inflammation) in the nasal passages.
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Generic name: triamcinolone acetonide
Pronunciation: (TRYE-am-SIN-oh-lone)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Nasal Allergy
Indications
The following indications are listed for Nasal Allergy:
- Allergic Rhinitis
- Allergic Rhinitis Prevention
- Chronic Non-Allergic Rhinitis
- Perennial Allergic Rhinitis
Also known as: Allergic Rhinitis Prophylaxis, Atopic Rhinitis, Chronic Nonallergic Rhinitis, Non-Seasonal Allergic Rhinitis.
Dosing
The nasal aqueous suspension spray pump delivers about 55 mcg of triamcinolone acetonide per metered spray.
Triamcinolone acetonide is administered by nasal inhalation as an aqueous suspension using a spray pump. Patients should be carefully instructed in the use of the nasal inhalation spray pump, including the need to prime the pump prior to first use and after a period of nonuse (i.e., 2 weeks or more).
Prior to administration of the nasal suspension, patients should be instructed to shake the container well. Patients should gently blow the nose to clear their nasal passages. Patients should tilt the head slightly backward and insert the spray tip into one nostril, pointing the tip toward the back of the nose. The drug suspension should be sprayed into one nostril while holding the other nostril closed and concurrently inspiring through the nose. This procedure should be repeated for the other nostril. Patients should avoid blowing the nose for 15 minutes after inhalation.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
Known hypersensitivity to triamcinolone acetonide or any ingredient in the respective formulations.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
Adverse effects occurring in at least 2% of adults and children 12 years of age or older receiving triamcinolone acetonide nasal aqueous suspension in clinical trials and more frequently than with placebo included pharyngitis, epistaxis, and increased cough.
Adverse effects occurring in more than 2% of children 4-12 years of age receiving triamcinolone acetonide nasal aqueous suspension in clinical trials and more frequently than with placebo included flu syndrome, increased cough, pharyngitis, bronchitis, dyspepsia, and tooth disorder.
Adverse effects occurring in at least 2% of children 2-5 years of age receiving triamcinolone acetonide nasal aqueous suspension in one study and more frequently than with placebo included headache, pharyngolaryngeal pain, epistaxis, nasopharyngitis, upper abdominal pain, diarrhea, asthma, rash, excoriation, and rhinorrhea.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
Safety and efficacy of intranasal triamcinolone acetonide suspension have not been established in children younger than 2 years of age. Intranasal corticosteroids may cause a reduction in growth velocity in pediatric patients.
Category C. Hypoadrenalism may occur in infants born to women receiving corticosteroids during pregnancy; these infants should be monitored carefully.
Not known whether triamcinolone acetonide is distributed into milk. Caution is advised if the drug is administered in nursing women.
Experience from clinical trials in those 65 years of age or older is insufficient to determine whether they respond differently from younger adults. Based on other reported clinical experience to date, no substantial differences in safety and efficacy relative to younger adults is apparent.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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