Endur-Thine (niacin/pantethine)

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Niacin and niacinamide are administered orally.

No dosing information is available for this tab.

No dosing information is available for this tab.

Niacin reportedly potentiates the hypotensive effect of ganglionic blocking drugs.

Long-term administration of isoniazid may interfere with the conversion of dietary tryptophan to niacin and increase the requirement of niacin.

There are no contraindication interactions for this drug.

There are no severe interactions for this drug.

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

• Arterial hemorrhage
• Disease of liver

• Alcohol use disorder
• Peptic ulcer

• 30 day risk period post-myocardial infarction
• Diabetes mellitus
• Gout
• Hypophosphatemia
• Hypotension
• Increased risk of bleeding due to coagulation disorder

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Rare or Very Rare

• Abnormal hepatic function tests
• Anaphylaxis
• Angioedema
• Atrial fibrillation
• Drug-induced hepatitis
• Dyspnea
• Edema
• Jaundice
• Laryngeal edema
• Laryngismus
• Macular retinal edema
• Myopathy
• Paresthesia
• Peptic ulcer
• Urticaria
• Vesicular rash

More Frequent

• Cough
• Diarrhea
• Dyspepsia
• Flushing
• Nausea
• Pruritus of skin
• Vomiting

Less Frequent

• Cardiac arrhythmia
• Dizziness
• Dry skin
• Exacerbation of peptic ulcer
• Hyperglycemia
• Hyperuricemia
• Hypophosphatemia
• Myalgia
• Syncope

Rare or Very Rare

• Acquired acanthosis nigricans
• Blurred vision
• Chills
• Dyschromia
• Eructation
• Facial edema
• Flatulence
• General weakness
• Hyperhidrosis
• Hypoprothrombinemia
• Hypotension
• Insomnia
• Maculopapular rash
• Migraine
• Muscle weakness
• Nervousness
• Orthostatic hypotension
• Palpitations
• Peripheral edema
• Skin rash
• Stinging of skin
• Tachycardia
• Thrombocytopenic disorder

No enhanced messaging available.

No enhanced messaging available.

Administration of supplementary doses of niacin during pregnancy has not been associated with any adverse effects to the mother or fetus. However, toxicologic studies have not been performed with large doses of niacin, and large doses of the drug should not be used in women who are or may become pregnant unless the possible benefits outweigh the potential risks to the fetus.

Administration of supplementary doses of niacin during lactation has not been associated with any adverse effects to the mother or fetus.

No enhanced messaging available.