Lamisil At (terbinafine HCl)

Terbinafine hydrochloride is a synthetic allylamine antifungal agent.

Terbinafine hydrochloride is a synthetic allylamine antifungal agent. Terbinafine is derived from naphthalenemethanamine, and is structurally and pharmacologically related to naftifine.

Terbinafine is active in vitro against dermatophytes, including Epidermophyton floccosum, Trichophyton mentagrophytes, T. rubrum, T. verrucosum, Microsporum canis, and M. gypseum. The drug also is active in vitro against Malassezia furfur and some Candida, including C. albicans and C. parapsillosis. The antifungal spectrum of activity of terbinafine is similar to that of naftifine.

Terbinafine usually is fungicidal in action against susceptible dermatophytes, but may be fungicidal or fungistatic against Candida. Terbinafine is more active than azole antifungals (e.g., itraconazole, ketoconazole) against dermatophytes, but is less active than these drugs against Candida.

Following topical application of terbinafine hydrochloride 1% cream or 1% solution to healthy skin, percutaneous absorption occurs and terbinafine concentrations attained in the stratum corneum are similar with both preparations. Terbinafine is absorbed systemically following topical application to intact skin, and low concentrations of the drug are attained in plasma. Systemically absorbed terbinafine is extensively metabolized.

Approximately 75% of percutaneously absorbed terbinafine is eliminated in urine, principally as metabolites. Following topical application to skin, the half-life of systemically absorbed terbinafine is approximately 21 hours.

USES: This medication is used to treat a variety of fungal skin infections such as ringworm, athlete's foot, and jock itch. This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Terbinafine is an antifungal that works by preventing the growth of fungus.

Generic name: terbinafine HCl
Pronunciation: (ter-BIN-uh-feen)
Drug class: Topical Antifungals
Therapeutic class: Dermatological

The following indications are listed for Lamisil At:

• Tinea Corporis
• Tinea Cruris
• Tinea Pedis

Also known as: Corporeal Ringworm, Dermatomycosis Pedis, Dhobie Itch, Eczema Marginatum, Jock Itch, Tinea Circinata, Tinea Glabrosa, Tinea Inguinalis, Tinea Of The Foot.