Cyproheptadine (cyproheptadine HCl)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Cyproheptadine is a first generation antihistamine and a serotonin antagonist.
USES: Cyproheptadine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. This medication also blocks another natural substance in your body (serotonin).
This medication should not be used in newborn or premature infants.
Generic name: cyproheptadine HCl
Pronunciation: (SYE-proe-HEP-ta-deen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Cyproheptadine
Indications
The following indications are listed for Cyproheptadine:
- Allergic Conjunctivitis
- Allergic Rhinitis
- Anaphylaxis Adjunct
- Dermatographic Urticaria
- Nasal Congestion
- Pruritus Of Skin
- Rhinorrhea
- Sneezing
- Urticaria
- Vasomotor Rhinitis
Also known as: Adjunct Medication Therapy For Anaphylactic Reaction, Adjunct Medication Therapy For Anaphylaxis, Allergy Eye Itch, Atopic Conjunctivitis, Autographism, Cnidosis, Dermatography, Dermographia, Dermographism, Dermography, Ebbecke's Reaction, Factitious Urticaria, Itching Wheals, Itchy Eyes Due To Allergies, Itchy Skin Eruption, Nasal Stuffiness, Nettle Rash, Ocular Itching Due To Allergies, Pruritic Dermatitis, Skin Writing, Uredo, Urticaria Factitia, Urticarial Rash, Urtication, Weal.
Dosing
Dosage of cyproheptadine hydrochloride should be individualized according to the patient's response and tolerance. For geriatric patients, the manufacturer suggests that cyproheptadine hydrochloride dosage be initiated in the lower end of the usual range.
Cyproheptadine hydrochloride is administered orally.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Reproduction studies in rabbits, mice, and rats using oral or subcutaneous cyproheptadine hydrochloride dosages up to 32 times the maximum recommended human oral dosage have not revealed evidence of harm to the fetus. Although the drug has been fetotoxic in rats when administered intraperitoneally at dosages 4 times the maximum recommended human oral dosage, experience in a limited number of women who received cyproheptadine orally during the first, second, and/or third trimesters of pregnancy did not reveal evidence of an increased risk of fetal abnormalities, nor were teratogenic effects observed in neonates born to these women. No evidence of adverse fetal effect was evident in an infant born to a woman who had received 12 mg of cyproheptadine hydrochloride daily throughout pregnancy for the treatment of Cushing's syndrome; the infant developed normally until 4 months of age when he developed gastroenteritis and died. Nevertheless, because the reported experience to date in humans cannot exclude the possibility of adverse fetal effects of the drug, cyproheptadine should be used during pregnancy only when clearly needed.
It is not known whether cyproheptadine hydrochloride is distributed into milk. Because of the potential for serious adverse reactions to cyproheptadine in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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