Tofranil (imipramine HCl)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Imipramine is a dibenzazepine-derivative tricyclic antidepressant.
USES: This medication is used to treat depression. It is also used to treat nighttime bed-wetting (enuresis) in children. Imipramine belongs to a class of drugs known as tricyclic antidepressants.
It works by helping to restore the balance of certain natural substances in the brain. For bed-wetting, this medication may work by blocking the effect of a certain natural substance (acetylcholine) on the bladder.
Generic name: imipramine HCl
Pronunciation: (ih-MIH-pra-meen)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Tofranil
Indications
The following indications are listed for Tofranil:
- Depression
- Nocturnal Enuresis
Also known as: Depressed Mood, Depressive Disorder, Depressive Reaction, Depressive Syndrome, Mental Depression.
Dosing
Dosage of imipramine salts is expressed in terms of imipramine hydrochloride.
Patients should be monitored for possible worsening of depression, suicidality, or unusual changes in behavior, especially at the beginning of therapy or during periods of dosage adjustment. (See Cautions: Precautions and Contraindications, in the Tricyclic Antidepressants General Statement 28:16.04.28.)
Imipramine hydrochloride and imipramine pamoate are administered orally. Although imipramine hydrochloride has been administered in up to 4 divided doses throughout the day, it is long-acting and the entire oral daily dose may be administered at one time. Imipramine pamoate may also be used to administer the daily oral dose of imipramine, but it has no advantages over the hydrochloride. Administration of the entire daily dose at bedtime may reduce daytime sedation; patients who experience insomnia and stimulation may be given the entire daily dose in the morning.
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No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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