Provocholine (methacholine chloride)
Inhalation Vial, Nebulizer (Ea); Inhalation Vial, Nebulizer (Ml)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Generic name: methacholine chloride
Therapeutic class: Diagnostic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Provocholine
Indications
The following indications are listed for Provocholine:
- Diagnostic Test For Asthma
Also known as: Diagnostic Procedure For Asthma.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
Moderate Interaction: Assess the risk to the patient and take action as needed.
Methacholine/Beta-Agonists; Anticholinergics; Theophylline
SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.
MECHANISM OF ACTION: Beta-agonists, anticholinergics, and theophylline may inhibit the action of methacholine on the airway.(1)
CLINICAL EFFECTS: The result of the methacholine challenge test may not be accurate.(1)
PREDISPOSING FACTORS: None determined.
PATIENT MANAGEMENT: The following drugs should be held before a methacholine challenge for the the duration indicated:(1) - short-acting beta-agonists: 6 hours - long-acting beta-agonists: 36 hours - short-acting anti-cholinergics: 12 hours - long-acting anti-cholinergics: at least 168 hours (7 days) - oral theophylline: 12-48 hours
DISCUSSION: Beta-agonists, anticholinergics, and theophylline may inhibit the action of methacholine on the airway and cause inaccurate test results.
Contraindications
There is no enhanced messaging for this drug.
- 30 day risk period post-myocardial infarction
- Aortic aneurysm
- Cerebrovascular accident
- Pregnancy
- Bradycardia
- Increased gastric tonus
- Peptic ulcer
- Seizure disorder
- Urinary tract obstructive uropathy
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
Rare or Very Rare
- Acute bronchospasm
- Bronchospastic pulmonary disease
- Dyspnea
- Wheezing
Less Frequent
- Dizziness
- Headache disorder
- Pharyngitis
Rare or Very Rare
- Chest tightness
- Cough
- Pruritus of skin
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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