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Clorazepate Dipotassium (clorazepate dipotassium)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Clorazepate dipotassium is a benzodiazepine.

USES: Clorazepate is used to treat anxiety, acute alcohol withdrawal, and seizures. This medication belongs to a class of drugs called benzodiazepines. It works by calming your brain and nerves.

Generic name: clorazepate dipotassium
Pronunciation: (klor-AZ-e-pate)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Clorazepate Dipotassium:

  • Alcohol Withdrawal Syndrome
  • Anxiety
  • Partial Epilepsy Treatment Adjunct

Also known as: Acute Alcohol Withdrawal, Etoh Withdrawal, Partial Onset Seizures Treatment Adjunct, Partial Seizures Treatment Adjunct.

Dosing

Dosage of clorazepate dipotassium must be carefully individualized, and the smallest effective dosage should be used (especially in geriatric or debilitated patients and in those with liver disease or low serum albumin) to avoid oversedation. Since the metabolites of clorazepate have long elimination half-lives, time to reach steady-state plasma concentrations should be considered when dosage adjustments are made. In patients who have received prolonged (e.g., for several months) clorazepate dipotassium therapy, abrupt discontinuance of the drug should be avoided since manifestations of withdrawal can be precipitated; if the drug is to be discontinued in such patients, it is recommended that dosage be gradually tapered. It is particularly important that the drug not be discontinued abruptly in patients with a history of a seizure disorder since seizures may be precipitated.

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

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Adverse reactions

There is no enhanced messaging for this drug.

Precautions

A boxed warning has been included in the prescribing information for all benzodiazepines describing the risks of abuse, misuse, addiction, physical dependence, and withdrawal reactions associated with all drugs in this class. Abuse and misuse can result in overdose or death, especially when benzodiazepines are combined with other medicines, such as opioid pain relievers, alcohol, or illicit drugs. Frequent follow-up with patients receiving benzodiazepines is important. Reassess patients regularly to manage their medical conditions and any withdrawal symptoms. Clinicians should assess a patient's risk of abuse, misuse, and addiction. Standardized screening tools are available (https://nida.nih.gov/nidamed-medical-health-professionals/screening-tools- resources/chart-screening-tools). To reduce the risk of acute withdrawal reactions, use a gradual dose taper when reducing the dosage or discontinuing benzodiazepines. Take precautions when benzodiazepines are used in combination with opioid medications.

Clorazepate dipotassium shares the toxic potentials of the benzodiazepines, and the usual precautions of benzodiazepine administration should be observed. (See Cautions in the Benzodiazepines General Statement 28:24.08.)

ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data