Arestin (minocycline HCl microspheres)
Periodontal Pocket Anti-Infectives Dental Cartridge (Ea)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Minocycline hydrochloride is a semisynthetic tetracycline antibiotic derived from tetracycline.
Minocycline hydrochloride is a semisynthetic tetracycline antibiotic. Minocycline hydrochloride is commercially available for subgingival administration as an extended-release powder that contains the drug incorporated into a bioresorbable polymer (microspheres).
The mechanism of action of the extended-release subgingival preparation of minocycline as an adjunct to scaling and root planing procedures in reduction of pocket depth in patients with adult periodontitis is unknown. Minocycline has antibacterial activity against some organisms associated with periodontal disease, but qualitative and quantitative changes in plaque microorganisms have not been demonstrated when the subgingival preparation of the drug was used in patients with periodontitis.
Minocycline is bacteriostatic in action and exerts its antimicrobial activity by inhibiting protein synthesis in susceptible organisms. The drug is active in vitro against some organisms associated with periodontal disease. Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum, Eikenella corrodens, and Actinobacillus actinomycetemcomitans are inhibited in vitro by minocycline concentrations of 8 mcg/mL or less.
At the conclusion of one clinical trial of 56 days' duration, there was no evidence of emergence of minocycline-resistant bacteria or changes in the presence of Candida albicans or Staphylococcus aureus in the GI tract in patients receiving minocycline hydrochloride extended-release powder for subgingival administration. However, in another clinical trial, at 9 months after initiation of subgingival minocycline hydrochloride therapy, the number of minocycline-resistant bacteria in the gingival crevicular fluid was increased slightly, but the clinical importance of this finding is not known.
USES: This medication is used to treat adult gum disease (periodontitis). Minocycline belongs to a class of drugs known as tetracycline antibiotics. It works by preventing the growth of bacteria.
This medication is a powder that your dental professional places into infected tooth pockets. Minocycline is then slowly released over the next several weeks.
Generic name: minocycline HCl microspheres
Pronunciation: (MIN-oh-SYE-kleen)
Drug class: Periodontal Pocket Anti-Infectives
Therapeutic class: Mouth-Throat-Dental - Preparations
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Arestin
Indications
The following indications are listed for Arestin:
- Periodontitis
Also known as: Alveolodental Osteoperiostitis, Cementoperiostitis, Paradentitis.
Dosing
Dosage of minocycline hydrochloride extended-release powder for subgingival administration is expressed in terms of minocycline.
Each commercially available unit-dose cartridge of minocycline hydrochloride extended-release powder delivers 1 mg of minocycline.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
No formal drug interaction studies have been performed with subgingival minocycline.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
Minocycline hydrochloride extended-release powder for subgingival administration is contraindicated in patients hypersensitive to minocycline or other tetracyclines.
- Pregnancy
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
Adverse effects occurring in 3% or more of patients receiving minocycline hydrochloride extended-release powder for subgingival administration include periodontitis, tooth disorder, tooth caries, dental pain, gingivitis, headache, infection, stomatitis, mouth ulceration, flu syndrome, pharyngitis, pain, dyspepsia, dental infection, and mucous membrane disorder.
More Frequent
- Infection
Rare or Very Rare
- Anaphylaxis
- Angioedema
- Dental discoloration
- Lupus-like syndrome
- Serum sickness
- Tooth enamel hypoplasia
- Urticaria
More Frequent
- Flu-like symptoms
- Headache disorder
- Mouth irritation
- Pain
Less Frequent
- Dyspepsia
- Gingivitis
- Pharyngitis
Rare or Very Rare
- Pruritus of skin
- Skin rash
Precautions
No enhanced messaging available.
Safety and efficacy of minocycline extended-release powder for subgingival administration have not been established in pediatric patients younger than 18 years of age. (See Dental and Bone Effects under Warnings/Precautions: Warnings, in Cautions.)
Minocycline extended-release powder for subgingival administration has not been evaluated in pregnant women. The effects of tetracyclines on labor and delivery are unknown.
Tetracyclines should not be used during pregnancy. If a tetracycline is used during pregnancy, the patient should be apprised of potential hazards to the fetus.
Minocycline and other tetracyclines are distributed into milk.
Tetracyclines should not be used in nursing women. Because of the potential for serious adverse reactions to tetracyclines in nursing infants, a decision should be made whether to discontinue nursing or minocycline, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Periodontitis | ||
| K04.4 | ICD10CM | Acute apical periodontitis of pulpal origin |
| K04.5 | ICD10CM | Chronic apical periodontitis |
| K05.2 | ICD10CM | Aggressive periodontitis |
| K05.20 | ICD10CM | Aggressive periodontitis, unspecified |
| K05.21 | ICD10CM | Aggressive periodontitis, localized |
| K05.211 | ICD10CM | Aggressive periodontitis, localized, slight |
| K05.212 | ICD10CM | Aggressive periodontitis, localized, moderate |
| K05.213 | ICD10CM | Aggressive periodontitis, localized, severe |
| K05.219 | ICD10CM | Aggressive periodontitis, localized, unspecified severity |
| K05.22 | ICD10CM | Aggressive periodontitis, generalized |
| K05.221 | ICD10CM | Aggressive periodontitis, generalized, slight |
| K05.222 | ICD10CM | Aggressive periodontitis, generalized, moderate |
| K05.223 | ICD10CM | Aggressive periodontitis, generalized, severe |
| K05.229 | ICD10CM | Aggressive periodontitis, generalized, unspecified severity |
| K05.3 | ICD10CM | Chronic periodontitis |
| K05.30 | ICD10CM | Chronic periodontitis, unspecified |
| K05.31 | ICD10CM | Chronic periodontitis, localized |
| K05.311 | ICD10CM | Chronic periodontitis, localized, slight |
| K05.312 | ICD10CM | Chronic periodontitis, localized, moderate |
| K05.313 | ICD10CM | Chronic periodontitis, localized, severe |
| K05.319 | ICD10CM | Chronic periodontitis, localized, unspecified severity |
| K05.32 | ICD10CM | Chronic periodontitis, generalized |
| K05.321 | ICD10CM | Chronic periodontitis, generalized, slight |
| K05.322 | ICD10CM | Chronic periodontitis, generalized, moderate |
| K05.323 | ICD10CM | Chronic periodontitis, generalized, severe |
| K05.329 | ICD10CM | Chronic periodontitis, generalized, unspecified severity |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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