Levobunolol Hcl (levobunolol HCl)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Levobunolol hydrochloride is a nonselective beta-adrenergic blocking agent.
USES: This medication is used alone or with other medications to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (such as ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. Levobunolol belongs to a class of drugs known as beta blockers and works by decreasing the amount of fluid production within the eye.
Generic name: levobunolol HCl
Pronunciation: (lee-voe-BYOO-noe-lole)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Levobunolol Hcl
Indications
The following indications are listed for Levobunolol Hcl:
- Ocular Hypertension
- Open Angle Glaucoma
Also known as: Chronic Glaucoma, Compensated Glaucoma, Glaucoma Simplex, Increased Intraocular Pressure, Increased Iop, Open-Angle Glaucoma, Raised Intraocular Pressure, Simple Glaucoma.
Dosing
No dosing information is available for this tab.
Levobunolol hydrochloride is applied topically to the eye as an ophthalmic solution. Care should be taken to avoid contamination of the solution container. (See Cautions: Precautions and Contraindications.)
Levobunolol ophthalmic solution contains benzalkonium chloride, which may be absorbed by soft contact lenses. The manufacturers state that soft contact lenses should be removed prior to administration of each dose but may be reinserted 15 minutes after the dose.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Reproduction studies in rats using oral levobunolol hydrochloride dosages up to 1800 times (i.e., 25 mg/kg) the usual human daily ocular dose have not revealed evidence of maternal toxicity or harm to the fetus. Fetotoxicity, as manifested by increased number of resorption sites, has been observed in rabbits using oral dosages of 1, 3, or 10 mg/kg daily, but it appears that rabbits may be particularly sensitive to beta-adrenergic blocking agents. Reproduction studies in pregnant ewes using IV racemic bunolol hydrochloride doses of 0.05 mg/kg revealed evidence of maternal and fetal bradycardia and inhibition of isoproterenol-induced agonist activity in both ewe and fetus.
There are no adequate and controlled studies to date using levobunolol hydrochloride ophthalmic solution in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.
It is not known whether levobunolol hydrochloride is distributed into milk. Because systemically administered beta-blockers and topical timolol maleate are distributed into milk, levobunolol should be used with caution in nursing women.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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