Caverject (alprostadil)

Alprostadil, the naturally occurring prostaglandin E1, is a vasodilating agent and a platelet-aggregation inhibitor.

Alprostadil, the naturally occurring prostaglandin E1, is a vasodilating agent and a platelet-aggregation inhibitor and is prepared synthetically for commercial use. Parenteral alprostadil is commercially available as a sterile powder for injection with (Caverject(R) Impulse(R)) or without alfadex (alpha-cyclodextrin) (Caverject(R)), as an alcoholic solution (Prostin VR Pediatric(R)), and as a lyophilized powder with alfadex (Edex(R)). The inclusion complex enhances the water solubility of alprostadil.

Alprostadil also is available as a urethral (micro) suppository, measuring 1.4 mm in diameter and 3 or 6 mm in length (Muse(R)). Prostaglandins of the E series occur naturally in the seminal vesicles and cavernous tissues of males and in the placenta and ductus arteriosus of the fetus. Alprostadil relaxes the smooth muscles of the corpus cavernosum and the ductus arteriosus.

Alprostadil is absorbed through the urethral mucosa and then distributed to corpus spongiosum and corpus cavernosum when administered as a urethral suppository.

USES: This medication is used to treat male sexual function problems (erectile dysfunction). It works by helping the blood flow into the penis to achieve and maintain an erection. This medication is not for use in women or children.

This medication is not recommended for use in men with penile implants. This medication does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Using an effective barrier method (latex or polyurethane condom/dental dams) during sexual activity will help to decrease your risk of infection.

Generic name: alprostadil
Pronunciation: (al-PROS-ta-dil)
Drug class: Alprostadil
Therapeutic class: Drugs to treat Erectile Dysfunction

The following indications are listed for Caverject:

• Erectile Dysfunction

Also known as: Impotency.