Nitrofurantoin (nitrofurantoin)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Nitrofurantoin is a synthetic, nitrofuran-derivative urinary antibacterial agent.
USES: Nitrofurantoin is an antibiotic used to treat or prevent certain bladder infections. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections.
It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections. This medication should not be used in infants younger than 1 month old (see also Precautions section).
This drug should not be used to treat infections outside the bladder (including kidney infections such as pyelonephritis or perinephric abscesses).
Generic name: nitrofurantoin
Pronunciation: (NYE-trow-fyour-AN-toe-in)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Nitrofurantoin
Indications
The following indications are listed for Nitrofurantoin:
- Bacterial Urinary Tract Infection
- E. Coli Urinary Tract Infection
- Enterobacter Cystitis
- Enterococcus Urinary Tract Infection
- Klebsiella Urinary Tract Infection
- Staphylococcus Aureus Urinary Tract Infection
Also known as: Cystitis Due To Aerobacter Species, Cystitis Due To Enterobacter Species, E. Coli Uti, Klebsiella Uti, Urinary Cystitis Due To Enterobacter Species, Urinary Tract Infection Due To Enterococcus Species, Urinary Tract Infection Due To Escherichia Coli, Urinary Tract Infection Due To Klebsiella Species, Urinary Tract Infection Due To Staphylococcus Aureus, Uti Due To Enterococcus Species, Uti Due To Staphylococcus Aureus.
Dosing
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Drug interactions
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There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
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There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Reproduction studies in rats and rabbits using nitrofurantoin in doses up to 6 times the usual human dose have not revealed evidence of harm to the fetus. However, growth retardation and a low incidence of minor and common malformations were observed when nitrofurantoin doses 68 times the usual human dose were administered to pregnant mice; fetal malformations were not observed following administration of nitrofurantoin doses 25 times the usual human dose. Lung papillary adenomas of unknown importance were observed in first generation offspring of mice whose mothers received nitrofurantoin doses 19 times the usual human dose. The relevance of these reproduction studies to humans is not known. There are no adequate and controlled studies to date using nitrofurantoin in pregnant women, and the drug should be used during pregnancy only when clearly indicated.
Nitrofurantoin is contraindicated in pregnant women at term (38-42 weeks gestation), including during labor and delivery or when onset of labor is imminent, because of the possibility of hemolytic anemia in the neonate secondary to immature enzyme systems.
Nitrofurantoin is distributed into milk. Because of the potential for adverse effects of nitrofurantoin in nursing infants younger than 1 month old or in infants who are known or suspected to have glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
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ICD codes
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Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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