Vitamin B-1 (thiamine HCl)
Vitamin B-1 Oral Tablet
Last reviewed · Source: First Databank (FDB) drug data
Overview
Thiamine is a water-soluble, B complex vitamin.
USES: Thiamine (vitamin B1) is used to prevent or treat low levels of vitamin B1 in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra vitamin B1. However, some conditions (such as alcoholism, cirrhosis, stomach/intestinal problems) can cause low levels of vitamin B1.
Vitamin B1 plays an important role in the body. It is needed to maintain the health of the nerves and the heart. Low levels of vitamin B1 may cause heart failure and mental/nerve problems.
Generic name: thiamine HCl
Pronunciation: (THYE-a-min)
Drug class: Vitamin B-1
Therapeutic class: Electrolyte Balance-Nutritional Products
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Vitamin B-1
Indications
The following indications are listed for Vitamin B-1:
- Thiamine Deficiency
- Wernicke-Korsakoff Syndrome
Also known as: Amnestic Syndrome Of Wernicke's Disease, Korsakoff's Psychosis, Korsakoff's Syndrome, Vitamin B1 Deficiency.
Dosing
No dosing information is available for this tab.
Thiamine hydrochloride is usually administered orally. When oral administration is not feasible, when malabsorption is suspected, or in patients with Wernicke's encephalopathy syndrome or high-output heart failure secondary to beriberi, the drug may be administered IM or IV; most clinicians prefer IV administration of thiamine hydrochloride for the treatment of high-output heart failure.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
Although the clinical importance is unknown, thiamine reportedly may enhance the effect of neuromuscular blocking agents.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
Moderate Interaction: Assess the risk to the patient and take action as needed.
Thiamine/Patiromer
SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.
MECHANISM OF ACTION: Patiromer may bind to thiamine.(1)
CLINICAL EFFECTS: Concurrent use may result in decreased gastrointestinal absorption and loss of efficacy of thiamine.(1)
PREDISPOSING FACTORS: None determined.
PATIENT MANAGEMENT: The US manufacturer of patiromer recommends administering patiromer at least 3 hours before or 3 hours after thiamine.(1)
DISCUSSION: An in vitro binding study found potentially clinically significant binding of thiamine by patiromer. It is recommended to take these drugs 3 hours apart.(1)
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
- Systemic mastocytosis
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Thiamine deficiency | ||
| E51 | ICD10CM | Thiamine deficiency |
| E51.1 | ICD10CM | Beriberi |
| E51.11 | ICD10CM | Dry beriberi |
| E51.12 | ICD10CM | Wet beriberi |
| E51.2 | ICD10CM | Wernicke's encephalopathy |
| E51.8 | ICD10CM | Other manifestations of thiamine deficiency |
| E51.9 | ICD10CM | Thiamine deficiency, unspecified |
| Wernicke-korsakoff syndrome | ||
| F10.26 | ICD10CM | Alcohol dependence with alcohol-induced persisting amnestic disorder |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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