Levorphanol Tartrate (levorphanol tartrate)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Levorphanol tartrate is an opiate agonist.

Levorphanol tartrate is a strong analgesic used in relief of moderate to severe pain. The drug is also used to relieve severe, intractable pain (e.g., in terminally ill patients). For further information on the role of opiate analgesics in the management of acute or chronic pain, see Uses: Pain, in the Opiate Agonists General Statement 28:08.08.

Generic name: levorphanol tartrate
Pronunciation: (lee-VOR-fa-nole)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Levorphanol Tartrate:

  • Pain

Dosing

Levorphanol tartrate should be given at the lowest effective dosage and for the shortest duration of therapy consistent with the treatment goals of the patient. Reduced dosage is indicated in poor-risk patients and in very old patients. If concomitant therapy with other CNS depressants is required, the lowest effective dosages and shortest possible duration of concomitant therapy should be used. The initial dose of levorphanol tartrate should be reduced by 50% or more in patients with compromised respiratory function and in those receiving other drugs that depress respiration.

The usual oral adult dosage of levorphanol tartrate is 2 mg every 6-8 hours as needed; the dosage may be increased to 3 mg every 6-8 hours if necessary.

When an ''around-the-clock'' dosing regimen is used, at least 72 hours should elapse between dosage adjustments.

For acute pain not related to trauma or surgery, the prescribed quantity should be limited to the amount needed for the expected duration of pain severe enough to require opiate analgesia (generally 3 days or less and rarely more than 7 days). When opiate analgesics are used for the management of chronic noncancer pain, the US Centers for Disease Control and Prevention (CDC) recommends that primary care clinicians carefully reassess individual benefits and risks before prescribing dosages equivalent to 50 mg or more of morphine sulfate daily and avoid dosages equivalent to 90 mg or more of morphine sulfate daily or carefully justify their decision to titrate the dosage to such levels. Other experts recommend consulting a pain management specialist before exceeding a dosage equivalent to 80-120 mg of morphine sulfate daily. For further information on the management of opiate analgesic therapy, see Dosage and Administration: Dosage, in the Opiate Agonists General Statement 28:08.08.

Drug interactions

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Contraindications

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Adverse reactions

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Precautions

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ICD codes

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Formulary status

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Last reviewed · Source: First Databank (FDB) drug data