Cosyntropin (cosyntropin)
Corticotropins Injection Vial (Ea)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Generic name: cosyntropin
Drug class: Corticotropins
Therapeutic class: Diagnostic Agents
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Cosyntropin
Indications
The following indications are listed for Cosyntropin:
- Diagnostic Test For Secondary Adrenocortical Insufficiency
Also known as: Diagnostic Exam For Secondary Adrenocortical Insufficiency, Diagnostic Test For Relative Adrenocortical Suppression.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
| Drug label | Dosing type | Instructions |
|---|---|---|
| Cosyntropin 0.25 Mg Vial | Maintenance | Inject 0.25 mg by intramuscular route once. |
| Drug label | Dosing type | Instructions |
|---|---|---|
| Cosyntropin 0.25 Mg Vial | Maintenance | Inject 0.25 mg by intramuscular route once. |
Drug interactions
There is no enhanced messaging for this drug.
Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient.
Cosyntropin/Agents Affecting Plasma Cortisol Levels
SEVERITY LEVEL: 1-Contraindicated Drug Combination: This drug combination is contraindicated and generally should not be dispensed or administered to the same patient.
MECHANISM OF ACTION: Agents affecting plasma cortisol levels may impact the accuracy of the cosyntropin diagnostic test.(1)
CLINICAL EFFECTS: Concurrent use of agents affecting plasma cortisol levels may impact the accuracy of the cosyntropin diagnostic test.(1)
PREDISPOSING FACTORS: None determined.
PATIENT MANAGEMENT: The US manufacturer of cosyntropin states accuracy of diagnosis using the cosyntropin diagnostic test may be complicated by concomitant medications affecting plasma cortisol levels.(1) Agents affecting plasma cortisol levels and recommendation to stop prior to cosyntropin diagnostic test include: - Glucocorticoids: May elevate plasma cortisol levels. Stop these drugs on the day of testing. Long-acting glucocorticoids may need to be stopped for a longer period before testing. - Spironolactone: May elevate plasma cortisol levels. Stop spironolactone on the day of testing. - Estrogen: May elevate plasma total cortisol levels. Discontinue estrogen containing drugs 4 to 6 weeks prior to testing to allow cortisol binding globulin levels to return to levels within the reference range. Alternatively, concomitant measurement of cortisol binding globulin at the time of testing can be done; if cortisol binding globulin levels are elevated, plasma total cortisol levels are considered inaccurate.(1)
DISCUSSION: Concurrent use of agents affecting plasma cortisol levels may impact the accuracy of the cosyntropin diagnostic test.(1)
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
- No disease contraindications
Adverse reactions
There is no enhanced messaging for this drug.
Less Frequent
- Anaphylaxis
Rare or Very Rare
- Bradycardia
- Hypersensitivity drug reaction
- Hypertension
Less Frequent
- Injection site sequelae
Rare or Very Rare
- Peripheral edema
- Skin rash
- Tachycardia
Precautions
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
| Code | Type | Description |
|---|---|---|
| Acute adrenocortical insufficiency | ||
| E27.2 | ICD10CM | Addisonian crisis |
| E27.40 | ICD10CM | Unspecified adrenocortical insufficiency |
ICD code information from First Databank (FDB).
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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