Miacalcin (calcitonin,salmon,synthetic)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Calcitonin, a polypeptide hormone secreted by the parafollicular cells (C cells) of the thyroid gland in mammals and by the ultimobranchial gland in birds and fish, acts predominantly on bone to lower serum calcium concentration and inhibit bone resorption.
Calcitonin salmon is prepared synthetically and contains the 32 amino acids in the same linear sequence as occurs in natural calcitonin of salmon origin. Calcitonin salmon also is prepared using recombinant DNA technology; calcitonin salmon prepared by recombinant DNA technology is structurally identical to calcitonin salmon produced by chemical synthesis.
USES: This medication is used to treat brittle bone disease (osteoporosis) in women who are at least 5 years past "the change of life" (menopause). Calcitonin works by slowing bone loss to help maintain strong bones and reduce your risk of fractures. This product has been withdrawn from the Canadian market due to safety problems.
Generic name: calcitonin,salmon,synthetic
Pronunciation: (KAL-si-TOE-nin)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Miacalcin
Indications
The following indications are listed for Miacalcin:
- Postmenopausal Osteoporosis
Also known as: Post-Menopausal Osteoporosis.
Dosing
Dosage of calcitonin salmon is expressed in terms of International Units (units).
Calcitonin salmon is administered by subcutaneous or IM injection. Calcitonin salmon also is administered intranasally as a nasal spray.
Skin testing prior to initiation of therapy should be considered for patients with suspected sensitivity to calcitonin salmon. A skin test protocol is available from the Medical Services Department of Novartis Pharmaceutical Corporation or Upsher-Smith Laboratories.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
Formal drug interaction studies have not been performed to date.
Prior use of bisphosphonates in patients with Paget disease appears to reduce the antiresorptive response to intranasal calcitonin salmon in these patients.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
No enhanced messaging available.
No enhanced messaging available.
Calcitonin salmon has been shown to decrease fetal birthweight in rabbits when given in dosages 14-56 times the recommended human parenteral dose. Because calcitonin does not cross the placenta, this adverse fetal effect may result from metabolic effects of calcitonin in the pregnant animal. Parenteral calcitonin salmon should be used during pregnancy only when the potential benefits justify the possible risks to the fetus. Calcitonin salmon nasal spray should not be used in pregnant women.
Calcitonin inhibits lactation in animals. It is not known whether calcitonin salmon is distributed into milk, although drug distributed into milk and ingested by the infant is likely to be inactivated in the GI tract and therefore unlikely to be absorbed by the nursing infant. Because studies to determine GI absorption of calcitonin in nursing infants have not been performed to date, use of calcitonin salmon in nursing women is not recommended.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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