Apexol (salicylic acid/sulfacetamide sodium)

No dosing information is available for this tab.

Salicylic acid is applied topically to the skin as a cake, cream, gel, lotion, ointment, pledget, plaster, shampoo, solution, or suspension. Topical preparations of salicylic acid are for external use only. Contact with the eyes should be avoided; if contact occurs, the affected eye(s) should be washed thoroughly with water.

Prior to topical application, the affected area(s) to be treated should be cleansed and allowed to dry. Prior to removal of warts, corns, and calluses, the affected area may be soaked in warm water for 5 minutes.

Salicylic acid is commercially available in various preparations, some of which are intended for self-medication; the manufacturer's product labeling should be consulted for complete directions regarding appropriate dosage and administration of specific products.

No dosing information is available for this tab.

No dosing information is available for this tab.

There is no enhanced messaging for this drug.

There are no contraindication interactions for this drug.

Severe Interaction: Action is required to reduce the risk of severe adverse interaction.

Topical Sodium Sulfacetamide/Topical Silver

SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction.

MECHANISM OF ACTION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2)

CLINICAL EFFECTS: Concurrent application of topical sodium sulfacetamide and topical silver preparations may result in decreased clinical effectiveness of the products.(1,2)

PREDISPOSING FACTORS: None determined.

PATIENT MANAGEMENT: Avoid using topical silver preparations on the same location as topical sodium sulfacetamide products.(1,2)

DISCUSSION: Topical sodium sulfacetamide and topical silver are physically incompatible.(1,2)

There are no moderate interactions for this drug.

There is no enhanced messaging for this drug.

• Aspirin exacerbated respiratory disease
• Glucose-6-phosphate dehydrogenase (g6Pd) deficiency
• Hemoglobin H disease
• Hemolytic anemia from pyruvate kinase and g6PD deficiencies

There are no severe contraindications for this drug.

• Peripheral vascular disease

There is no enhanced messaging for this drug.

Rare or Very Rare

• Agranulocytosis
• Anaphylaxis
• Blood dyscrasias
• Burns
• Dyspnea
• Erythema
• Facial edema
• Glucose-6-phosphate dehydrogenase (g6Pd) deficiency anemia
• Hepatic necrosis
• Hypersensitivity drug reaction
• Hypersensitivity drug reaction
• Periorbital edema
• Pharyngeal edema
• Pruritus of skin
• Skin irritation
• Skin rash
• Skin ulcer
• Stevens-johnson syndrome
• Superficial skin ulcer
• Syncope
• Systemic lupus erythematosus
• Throat constriction
• Toxic epidermal necrolysis
• Urticaria

More Frequent

• Stinging of skin

Less Frequent

• Dry skin
• Skin irritation

Rare or Very Rare

• Pruritus of skin

No enhanced messaging available.

No enhanced messaging available.

There are no adequate and well-controlled studies of topical salicylic acid in pregnant women; the drug should be used during pregnancy only if the potential benefits justify the possible risks to the fetus.

Because of the potential for serious adverse reactions to salicylic acid in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman. If used in nursing women, the drug should not be applied to the chest area to avoid accidental contamination of the infant.

No enhanced messaging available.