Cycloserine (cycloserine)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Cycloserine, a structural analog of the amino acid d-alanine, is an antituberculosis antibiotic.
USES: This medication is used with other medications to treat tuberculosis (TB). In some cases, it may also be used to treat urinary tract infections (UTIs). It works by stopping the growth of bacteria.
This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Generic name: cycloserine
Pronunciation: (sye-klo-SER-een)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Cycloserine
Indications
The following indications are listed for Cycloserine:
- Active Tuberculosis
- E. Coli Urinary Tract Infection
- Enterobacter Cloacae Urinary Tract Infection
- Pulmonary Tuberculosis
Also known as: Active Tb, Acute Tuberculosis, E. Coli Uti, Pulmonary Tb, Urinary Tract Infection Due To Enterobacter Cloacae, Urinary Tract Infection Due To Escherichia Coli, Uti Due To Enterobacter Cloacae.
Dosing
Dosage of cycloserine in patients with renal impairment must be adjusted according to the degree of dysfunction and blood cycloserine concentrations.
Cycloserine is administered orally.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is some evidence that adverse nervous system effects of cycloserine, ethionamide, and isoniazid may be additive; therefore, cycloserine should be used with caution in patients receiving ethionamide or isoniazid.
Cycloserine inhibits the hepatic metabolism of phenytoin. Patients receiving both drugs should be observed for evidence of phenytoin intoxication, and the dosage of the anticonvulsant should be reduced if necessary.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
There is no enhanced messaging for this drug.
There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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No enhanced messaging available.
Reproduction studies in 2 generations of rats receiving cycloserine in dosages up to 100 mg/kg daily have not revealed evidence of teratogenicity. There are no adequate and controlled studies to date using cycloserine in pregnant women, and the drug should be used during pregnancy only when clearly needed. Because cycloserine crosses the placenta and data are limited regarding safety of the drug in pregnant women, the American Thoracic Society (ATS), US Centers for Disease Control and Prevention (CDC), and Infectious Diseases Society of America (IDSA) state that the drug should be used for the treatment of tuberculosis during pregnancy only when there are no suitable alternatives.
Because of the potential for adverse effects from cycloserine in nursing infants, a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the woman.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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