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Zaroxolyn (metolazone)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Metolazone, which is structurally and pharmacologically similar to thiazides, is a diuretic and antihypertensive agent.

Metolazone shares the uses of the thiazide diuretics; however, there is some evidence that metolazone may be more effective than other thiazide-like diuretics in the management of edema in patients with impaired renal function.

Generic name: metolazone
Pronunciation: (me-TOLE-a-zone)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Zaroxolyn:

  • Hypertension
  • Peripheral Edema Due To Chronic Heart Failure
  • Pulmonary Edema Due To Chronic Heart Failure
  • Renal Disease With Edema

Also known as: Edema Associated With Renal Insufficiency, Elevated Blood Pressure, Essential Hypertension, Hyperpiesia, Hyperpiesis, Hypertensive Disorder, Peripheral Edema Due To Chf, Peripheral Edema Due To Congestive Heart Failure, Pulmonary Edema Due To Congestive Heart Failure, Systemic Arterial Hypertension.

Dosing

Dosage of metolazone depends on the specific formulation used and condition being treated and should be individualized according to the patient's requirements and response. Mykrox(R) tablets (no longer commercially available in the US) were more rapidly and extensively absorbed than other metolazone formulations and were not therapeutically equivalent to Zaroxolyn(R) or other formulations of the drug that share the latter's slower and incomplete absorption. Mykrox(R) and bioequivalent formulations should not be interchanged with Zaroxolyn(R) and bioequivalent formulations. If metolazone is added to the regimen of a patient stabilized on a potent hypotensive agent, the dosage of the hypotensive agent should initially be reduced to avoid the possibility of severe hypotension.

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

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Adverse reactions

There is no enhanced messaging for this drug.

Precautions

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ICD codes

No ICD codes are available for this drug.

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data