B-Complex With B-12 (thiamine HCl/riboflavin/niacinamide/cyanocobalamin/protease)
Vitamin B-1 Oral Tablet
Last reviewed · Source: First Databank (FDB) drug data
Overview
Generic name: thiamine HCl/riboflavin/niacinamide/cyanocobalamin/protease
Drug class: Vitamin B-1
Therapeutic class: Electrolyte Balance-Nutritional Products
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on B-Complex With B-12
Indications
No indications are available for this drug.
Dosing
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
Moderate Interaction: Assess the risk to the patient and take action as needed.
Thiamine/Patiromer
SEVERITY LEVEL: 3-Moderate Interaction: Assess the risk to the patient and take action as needed.
MECHANISM OF ACTION: Patiromer may bind to thiamine.(1)
CLINICAL EFFECTS: Concurrent use may result in decreased gastrointestinal absorption and loss of efficacy of thiamine.(1)
PREDISPOSING FACTORS: None determined.
PATIENT MANAGEMENT: The US manufacturer of patiromer recommends administering patiromer at least 3 hours before or 3 hours after thiamine.(1)
DISCUSSION: An in vitro binding study found potentially clinically significant binding of thiamine by patiromer. It is recommended to take these drugs 3 hours apart.(1)
Contraindications
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- Leber's hereditary optic atrophy
- Gastrointestinal obstruction
- Meconium ileus
- Atrophic gastritis
- Crohn's disease
- Fibrosing colonopathy
- Gastrointestinal tract surgery
- Gout
- Hyperuricemia
- Hypokalemia
- Short bowel syndrome
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
Less Frequent
- Diarrhea
- Pruritus of skin
Precautions
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No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
No enhanced messaging available.
ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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