Pyridoxine Hcl - Drug Information | Physicians Office Resource

Overview

Vitamin B6 (as pyridoxine, pyridoxal, and pyridoxamine) is a water-soluble, B complex vitamin.

USES: Pyridoxine (vitamin B6) is used to prevent or treat low levels of vitamin B6 in people who do not get enough of the vitamin from their diets. Most people who eat a normal diet do not need extra vitamin B6. However, some conditions (such as alcoholism, liver disease, overactive thyroid, heart failure) or medications (such as isoniazid, cycloserine, hydralazine, penicillamine) can cause low levels of vitamin B6.

Vitamin B6 plays an important role in the body. It is needed to maintain the health of nerves, skin, and red blood cells. Pyridoxine has been used to prevent or treat a certain nerve disorder (peripheral neuropathy) caused by certain medications (such as isoniazid).

It has also been used to treat certain hereditary disorders (such as xanthurenic aciduria, hyperoxaluria, homocystinuria).

Generic name: pyridoxine HCl (vitamin B6)
Pronunciation: (PIR-i-DOX-een)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Pyridoxine Hcl:

Drug-Induced Pyridoxine Deficiency
Pyridoxine Deficiency
Pyridoxine-Dependent Seizure

Also known as: Pyridoxine-Dependent Epilepsy, Pyridoxol-Dependent Seizures, Vitamin B6 Dependent Convulsions.

Dosing

Although pyridoxine was previously considered nontoxic even at high dosages, current evidence indicates that chronic administration of large dosages (e.g., 2 g daily) for the management of various conditions can cause severe adverse neurologic effects, and the risk to benefit of such dosages must be carefully weighed. (See Chronic Toxicity.)

Drug interactions

Pyridoxine hydrochloride reverses the therapeutic effects of levodopa by accelerating peripheral metabolism of levodopa. Concomitant administration of carbidopa with levodopa prevents the reversal by pyridoxine of levodopa's effects. Pyridoxine hydrochloride should not be administered in dosages greater than 5 mg daily to patients receiving levodopa alone.

In one study, 200 mg of pyridoxine hydrochloride daily for 1 month resulted in a 50% decrease in serum concentrations of phenobarbital and phenytoin.

Although isoniazid interferes with pyridoxine metabolism, the American Academy of Pediatrics (AAP) states that children receiving isoniazid do not need pyridoxine supplements unless they have or are likely to have nutritional deficiencies. The AAP currently recommends that children and adolescents receiving meat- and milk-deficient diets, those with nutritional deficiencies (including symptomatic children with human immunodeficiency virus (HIV) infection), infants who are breast-feeding and their mothers, and pregnant women receive pyridoxine supplements.

Contraindications

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Adverse reactions

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Precautions

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ICD codes

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Formulary status

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Pyridoxine Hcl (pyridoxine HCl (vitamin B6))