Cefaclor (cefaclor)
Last reviewed · Source: First Databank (FDB) drug data
Overview
Cefaclor is a semisynthetic, second generation cephalosporin antibiotic.
Cefaclor is used orally for the treatment of acute otitis media caused by susceptible bacteria; pharyngitis and tonsillitis caused by Streptococcus pyogenes (group A beta-hemolytic streptococci); mild to moderate upper and lower respiratory tract infections (including pneumonia) caused by susceptible bacteria; uncomplicated skin and skin structure infections caused by susceptible bacteria; and urinary tract infections (including pyelonephritis and cystitis) caused by susceptible bacteria. While commercially available cefaclor capsules and oral suspension can be used for any of these infections, safety and efficacy of cefaclor extended-release tablets have been established only for the treatment of mild to moderate respiratory tract infections (i.e., acute exacerbations of chronic bronchitis, secondary infections of acute bronchitis) caused by susceptible bacteria; pharyngitis and tonsillitis caused by S. pyogenes; and mild to moderate uncomplicated skin and skin structure infections caused by susceptible Staphylococcus aureus (methicillin-susceptible (oxacillin-susceptible) strains only).
Generic name: cefaclor
Pronunciation: (SEF-a-klor)
Reference product & biosimilars
No reference, biosimilar or interchangeable associated with this drug.
Today’s intelligence on Cefaclor
Indications
The following indications are listed for Cefaclor:
- Acute Bacterial Otitis Media
- Bacterial Urinary Tract Infection
- Haemophilus Influenzae Pneumonia
- Lower Respiratory Infection
- Pharyngitis
- Pneumonia
- Skin And Skin Structure Infection
- Streptococcal Pneumonia
- Tonsillitis
- Upper Respiratory Infection
Also known as: Acute Upper Respiratory Tract Infection, Acute Uri, Bacterial Otitis Media, H. Flu Pneumonia, H. Influenzae Pneumonia, Hemophilus Influenzae Pneumonia, Infection Of Skin And/Or Subcutaneous Tissue, Influenza Bacillus Pneumonia, Lower Respiratory Tract Infection, Pfeiffer's Bacillus Pneumonia, Pneumonia Due To Haemophilus Influenzae, Pneumonia Due To Streptococcus Species, Pneumonia Due To Streptococcus Spp., Skin And Soft Tissue Skin Infection, Throat Inflammation.
Dosing
Cefaclor is commercially available as the monohydrate; dosage is expressed in terms of anhydrous cefaclor.
Modification of usual cefaclor dosage is not necessary in patients with renal impairment; however, close clinical observation and appropriate laboratory tests are recommended in patients with moderate or severe renal impairment since experience in such patients is limited.
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No dosing information is available for this tab.
No dosing information is available for this tab.
Drug interactions
There is no enhanced messaging for this drug.
There are no contraindication interactions for this drug.
There are no severe interactions for this drug.
There are no moderate interactions for this drug.
Contraindications
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There are no contraindication contraindications for this drug.
There are no severe contraindications for this drug.
There are no moderate contraindications for this drug.
Adverse reactions
There is no enhanced messaging for this drug.
There are no severe adverse reactions for this drug.
There are no less severe adverse reactions for this drug.
Precautions
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Reproduction studies in mice, rats, and ferrets using doses up to 3-5 times the maximum human dosage (1500 mg daily) based on mg/m2 have not revealed evidence of harm to the fetus. There are no adequate and controlled studies using cefaclor in pregnant women or during labor and delivery, and the drug should be used during pregnancy only when clearly needed.
Because low concentrations of cefaclor (0.16-0.21 mcg/mL) have been detected in milk following a single 500-mg oral dose of the drug, cefaclor should be used with caution in nursing women.
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ICD codes
No ICD codes are available for this drug.
Formulary status
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Last reviewed · Source: First Databank (FDB) drug data
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