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Antivenin Micrurus Fulvius (antivenin,Micrurus fulvius)

Injection Vial (Ea)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Antivenin (Micrurus fulvius) (equine) is a preparation of equine immunoglobulins capable of neutralizing the venom of the Eastern coral snake (Micrurus fulvius fulvius) and Texas coral snake (M. fulvius tenere).

Antivenin (Micrurus fulvius) (equine) is used in the treatment of envenomation caused by bites of the Eastern coral snake (Micrurus fulvius fulvius) and the Texas coral snake (M. f. tenere). The antivenom is not effective against the venoms of the Arizona or Sonoran coral snake (Micruroides euryxanthus) or the venoms of Crotalinae (pit vipers, crotalines; formerly known as Crotalidae or crotalids) and should not be used in the management of envenomations related to these snakes. Antivenin (Micrurus fulvius) (equine) should never be administered prophylactically in asymptomatic patients.

Sensitivity testing (e.g., intradermal skin test) should be conducted in all individuals prior to administration of antivenin (Micrurus fulvius) (equine). (See Dosage and Administration: Sensitivity Testing and Desensitization.)

Generic name: antivenin,Micrurus fulvius
Therapeutic class: Biologicals

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Antivenin Micrurus Fulvius:

  • Envenomation By Coral Snake (Micrurus Fulvius)

Also known as: American Coral Snake Envenomation, Coral Snake Envenomization, Poisoned Bite Of Coral Snake, Poisoning Due To Bite Of Micrurus Fulvius, Poisoning Due To Venom Of Coral Snake, Poisoning Due To Venom Of Micrurus Fulvius, Toxic Effect Of Venom From A Coral Snake.

Dosing

When indicated, antivenin (Micrurus fulvius) (equine) should be administered as soon as possible, even before the onset of signs and symptoms of envenomation.

Dosage of antivenin (Micrurus fulvius) (equine) is expressed in terms of the number of vials of the antivenin.

The usual recommended initial IV dose of antivenin (Micrurus fulvius) (equine) in children and adults is 3-5 vials. Higher initial doses may be indicated in some individuals, depending on the nature and severity of the signs and symptoms of envenomation. Some clinicians suggest that 5-6 vials be given to coral snake bite victims if pain or neurologic signs or symptoms (e.g., paresthesia) are evident and that 8-10 vials may be given if bulbar signs of paralysis are present. Envenomation by large snakes may require relatively high doses, particularly in children or small adults. The dose of antivenom administered to children is not based on weight.

The need for additional doses of antivenom is based on the clinical response to the initial dose and continuing assessment of the patient and severity of poisoning. If necessary, additional antivenom may be administered, usually in doses of 1-5 vials. Venom yields determined under laboratory conditions suggest that some envenomed patients might require administration of a total dose of 10 or more vials of the antivenom to neutralize the venom injected by a biting snake.

Drug interactions

There is no enhanced messaging for this drug.

Contraindications

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Adverse reactions

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Precautions

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ICD codes

CodeTypeDescription
Envenomation by coral snake (micrurus fulvius)
T63.021AICD10CMToxic effect of coral snake venom, accidental (unintentional), initial encounter
T63.022AICD10CMToxic effect of coral snake venom, intentional self-harm, initial encounter
T63.023AICD10CMToxic effect of coral snake venom, assault, initial encounter
T63.024AICD10CMToxic effect of coral snake venom, undetermined, initial encounter

ICD code information from First Databank (FDB).

Formulary status

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Last reviewed · Source: First Databank (FDB) drug data