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Xyntha (antihemophilic factor (factor VIII) recomb,B-domain deleted)

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Last reviewed · Source: First Databank (FDB) drug data

Overview

Antihemophilic factor (recombinant) is a biosynthetic (recombinant DNA origin) preparation of antihemophilic factor (blood coagulation factor VIII). The drug is structurally similar to endogenous human factor VIII and produces the same biologic effects as plasma-derived antihemophilic factor (human).

USES: This medication is used to control and prevent bleeding episodes in people with low levels of factor VIII (hemophilia A). It is also used in these patients before surgery to prevent bleeding. People with low factor VIII levels are at risk for bleeding longer after an injury/surgery and for bleeding inside the body (especially into the joints and muscles).

This product contains a man-made form of factor VIII, also called antihemophilic factor. This product is used to temporarily replace the missing factor VIII, a protein (clotting factor) that is normally in the blood, so that the blood can clot and the bleeding can stop. This medication should not be used to treat von Willebrand disease.

Generic name: antihemophilic factor (factor VIII) recomb,B-domain deleted
Pronunciation: (AN-tye-HEE-moe-FIL-ik FAK-tor, ree-KOM-bi-nant)

Reference product & biosimilars

No reference, biosimilar or interchangeable associated with this drug.

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Indications

The following indications are listed for Xyntha:

  • Bleeding Episode In Hemophilia A
  • Bleeding Prevention In Hereditary Factor Viii Deficiency
  • Hemophilia A

Also known as: Bleeding Prevention In Classic Hemophilia, Bleeding Prevention In Congenital Factor Viii Deficiency, Bleeding Prevention In Hemophilia A, Bleeding Prophylaxis In Hemophilia A, Congenital Factor Viii Deficiency Disease, Hemorrhage Prophylaxis In Hemophilia A, Hemorrhaging In Hemophilia A, Prevention Of Bleeding Episode In Hemophilia A.

Dosing

Dosage of antihemophilic factor (recombinant) is expressed in terms of international units (IU, units) of antihemophilic factor activity; 1 unit is approximately equal to the quantity of antihemophilic factor present in 1 mL of fresh pooled human plasma. In general, administration of 1 unit/kg of antihemophilic factor (recombinant) will increase the circulating factor VIII level by approximately 2 units/dL (2%).

Drug interactions

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Contraindications

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Adverse reactions

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Precautions

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ICD codes

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Formulary status

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Last reviewed · Source: First Databank (FDB) drug data