Indication

Acute leukemia with lysine methyltransferase 2A gene (KMT2A) translocation

Acute leukemia with lysine methyltransferase 2A gene (*KMT2A*) translocation is an aggressive hematologic malignancy affecting the blood and bone marrow in pediatric, adult, and particularly infant populations. Read more about Acute leukemia with lysine methyltransferase 2A gene (KMT2A) translocation

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REVUFORJ (revumenib citrate)

ANTINEOPLASTIC - MENIN INHIBITORS·ACUTE LEUKEMIA WITH LYSINE METHYLTRANSFERASE 2A GENE (KMT2A) TRANSLOCATION·+1

SYNDAX PHARMACE

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About Acute leukemia with lysine methyltransferase 2A gene (KMT2A) translocation.

The disease spans acute myeloid leukemia, acute lymphoblastic leukemia, and mixed-phenotype acute leukemia, defined cytogenetically by balanced chromosomal rearrangements at chromosome band 11q23.

Pathophysiologically, these translocations create chimeric fusion oncoproteins that recruit epigenetic regulators to aberrantly upregulate critical oncogenic transcription programs, notably *HOXA* cluster genes and *MEIS1*.

This molecular mechanism results in blocked hematopoietic differentiation, uncontrolled blast proliferation, marked chemoresistance, and an unfavorable clinical prognosis.

nih.gov
Acute leukemia with lysine methyltransferase 2A gene (*KMT2A*) translocation is an aggressive hematologic malignancy affecting the blood and bone marrow in pediatric, adult, and particularly infant populations The disease spans acute myeloid leukemia, acute lymphoblastic leukemia, and mixed-phenotype acute leukemia, defined cytogenetically by balanced chromosomal rearrangements at chromosome band 11q23 This molecular mechanism results in blocked hematopoietic differentiation, uncontrolled blast ...
nih.gov
Acute leukemia with lysine methyltransferase 2A gene (*KMT2A*) translocation is an aggressive hematologic malignancy affecting the blood and bone marrow in pediatric, adult, and particularly infant populations
haematologica.org
Acute leukemia with lysine methyltransferase 2A gene (*KMT2A*) translocation is an aggressive hematologic malignancy affecting the blood and bone marrow in pediatric, adult, and particularly infant populations
nih.gov
The disease spans acute myeloid leukemia, acute lymphoblastic leukemia, and mixed-phenotype acute leukemia, defined cytogenetically by balanced chromosomal rearrangements at chromosome band 11q23 Pathophysiologically, these translocations create chimeric fusion oncoproteins that recruit epigenetic regulators to aberrantly upregulate critical oncogenic transcription programs, notably *HOXA* cluster genes and *MEIS1*
wikipedia.org
The disease spans acute myeloid leukemia, acute lymphoblastic leukemia, and mixed-phenotype acute leukemia, defined cytogenetically by balanced chromosomal rearrangements at chromosome band 11q23
atlasgeneticsoncology.org
The disease spans acute myeloid leukemia, acute lymphoblastic leukemia, and mixed-phenotype acute leukemia, defined cytogenetically by balanced chromosomal rearrangements at chromosome band 11q23
nih.gov
Pathophysiologically, these translocations create chimeric fusion oncoproteins that recruit epigenetic regulators to aberrantly upregulate critical oncogenic transcription programs, notably *HOXA* cluster genes and *MEIS1* This molecular mechanism results in blocked hematopoietic differentiation, uncontrolled blast proliferation, marked chemoresistance, and an unfavorable clinical prognosis
nih.gov
This molecular mechanism results in blocked hematopoietic differentiation, uncontrolled blast proliferation, marked chemoresistance, and an unfavorable clinical prognosis

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